Hydramine and Thiotepa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydramine (diphenhydramine hydrochloride) and Thiotepa (thiotepa). Common drug interactions include aplastic anaemia among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydramine and Thiotepa. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Thiotepa?

Thiotepa has active ingredients of thiotepa. eHealthMe is studying from 8,097 Thiotepa users. Check the latest studies of Thiotepa.

On Jul, 10, 2026

66 people who take Hydramine and Thiotepa together, and have interactions are studied.

Hydramine and Thiotepa drug interactions.

What are the common drug interactions of Hydramine and Thiotepa, by gender? *:

female:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Bacteraemia (presence of bacteria in the blood)
Epstein-barr virus infection
Mucosal inflammation (infection of mucous membrane)
Aplasia (defective development or congenital absence of an organ or tissue)
Epistaxis (bleed from the nose)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)
Alanine aminotransferase increased
Aspartate aminotransferase increased

male:

Febrile neutropenia (fever with reduced white blood cells)
Diarrhoea
Acute respiratory failure
Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Death
Hepatic enzyme increased
Nausea (feeling of having an urge to vomit)
Parainfluenzae virus infection
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

What are the common drug interactions of Hydramine and Thiotepa, by age (0-1 to 60+)? *:

0-1:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Mucosal inflammation (infection of mucous membrane)

2-9:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Aplasia (defective development or congenital absence of an organ or tissue)
Diarrhoea
Febrile neutropenia (fever with reduced white blood cells)
Vomiting
Bacteraemia (presence of bacteria in the blood)
Epstein-barr virus infection
Chills (felling of cold)
Mucosal inflammation (infection of mucous membrane)
Abdominal pain

10-19:

n/a

20-29:

n/a

30-39:

Blood pressure decreased
Pneumonia

40-49:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dilatation ventricular
Eating disorder
Fatigue (feeling of tiredness)
Headache (pain in head)
Leukopenia (less number of white blood cells in blood)
Metastases to lung (cancer spreads to lung)
Metastases to meninges (cancer spreads to meninges)
Visual acuity reduced (reduced clearness of vision)
Abdominal pain upper

50-59:

n/a

60+:

Febrile neutropenia (fever with reduced white blood cells)
Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Parainfluenzae virus infection
Systemic candida (whole body fungal infection)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 15 people, 22.73%
Bone Marrow Conditioning Regimen: 13 people, 19.70%
Burkitt Lymphoma (cancer of the lymphatic system): 5 people, 7.58%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 7.58%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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