Hydrea and Duragesic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrea (hydroxyurea) and Duragesic (fentanyl). Common drug interactions include death among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrea and Duragesic. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

What is Duragesic?

Duragesic has active ingredients of fentanyl. eHealthMe is studying from 66,597 Duragesic users. Check the latest studies of Duragesic.

On Jul, 20, 2026

26 people who take Hydrea and Duragesic together, and have interactions are studied.

What are the common drug interactions of Hydrea and Duragesic, by gender? *:

female:

Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Discomfort
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Ejection fraction decreased (systolic heart failure)
Gait abnormal
Haemorrhage intracranial (bleeding within the skull)
Hepatic failure (liver failure)
Hospitalisation

male:

Pain
Anxiety
Pyrexia (fever)
Rash
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Synovitis (inflammation of the synovial membrane)
Diarrhoea
Laceration (tearing of soft body tissue)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Vomiting

What are the common drug interactions of Hydrea and Duragesic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Aspartate aminotransferase increased
Blood lactate dehydrogenase increased
Pyrexia (fever)
Arthralgia (joint pain)
Blood bilirubin increased
Blood creatine decreased
Brain death
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Brain injury
Disseminated intravascular coagulation (systemic activation of blood coagulation)

30-39:

Joint effusion (presence of extra fluid in joint covering)
Osteonecrosis (death of bone)
Application site rash
Skin irritation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Gait abnormal
Pain

40-49:

Anxiety
Back injury
Dehydration (dryness resulting from the removal of water)
Depression
Drug abuser
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Gastroenteritis (inflammation of stomach and intestine)
Pain

50-59:

n/a

60+:

Blood calcium increased
Blood creatinine increased
Salivary hypersecretion (excess saliva secretion)
Skin ulcer
Stasis dermatitis (skin inflammation caused by blood pooling in the veins in your legs)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Cardiac failure congestive
Alanine aminotransferase increased
Arthralgia (joint pain)
Aseptic necrosis bone

What are the existing conditions these people have? *

Pain: 6 people, 23.08%
Thrombocytosis: 2 people, 7.69%
Osteoporosis (bones weak and more likely to break): 2 people, 7.69%
Nausea (feeling of having an urge to vomit): 2 people, 7.69%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 7.69%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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