Hydrea and Emend drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrea (hydroxyurea) and Emend (aprepitant). Common drug interactions include septic shock among females and photosensitivity reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrea and Emend. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

On Aug, 02, 2026

36 people who take Hydrea and Emend together, and have interactions are studied.

What are the common drug interactions of Hydrea and Emend, by gender? *:

female:

Septic shock (shock due to blood infection)
Toxic skin eruption (skin breakdown due to toxic substance)
Hypotension (abnormally low blood pressure)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Allergic transfusion reaction
Blood bilirubin increased
Blood lactate dehydrogenase increased
Bone marrow failure
Cardiac failure
Constipation

male:

Photosensitivity reaction
Burning sensation
Dry skin
Papule
Skin exfoliation (removal of the oldest dead skin cells)
Skin lesion

What are the common drug interactions of Hydrea and Emend, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Photosensitivity reaction
Burning sensation
Dry skin
Papule
Skin exfoliation (removal of the oldest dead skin cells)
Skin lesion

30-39:

Allergic transfusion reaction
Blood lactate dehydrogenase increased
Cardiac failure
Constipation
Diarrhoea
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Sepsis (a severe blood infection that can lead to organ failure and death)
Toxic skin eruption (skin breakdown due to toxic substance)
Vomiting

40-49:

n/a

50-59:

Febrile neutropenia (fever with reduced white blood cells)
Fungaemia (fungi circulate in the blood)
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Respiratory failure (inadequate gas exchange by the respiratory system)

60+:

Renal failure acute (rapid kidney dysfunction)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Blood bilirubin increased
Cytolytic hepatitis (dissolution or destruction of a liver cell)
N-terminal prohormone brain natriuretic peptide increased
Respiratory distress (difficulty in breathing)
Skin disorder (skin disease)
Toxic skin eruption (skin breakdown due to toxic substance)
Bilirubin conjugated increased
Hepatic steatosis (fatty liver disease)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 15 people, 41.67%
Acute Leukaemia (blood cancer): 9 people, 25.00%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 6 people, 16.67%
Renal Cell Carcinoma (a kidney cancer): 5 people, 13.89%
Tumor Lysis Syndrome: 4 people, 11.11%
Nausea And Vomiting: 4 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.33%
Allergic Rhinitis: 3 people, 8.33%
Asthma: 3 people, 8.33%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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