Hydrea and Imodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrea (hydroxyurea) and Imodium (loperamide hydrochloride). Common drug interactions include oropharyngeal pain among females and acute myeloid leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrea and Imodium. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 03, 2026

74 people who take Hydrea and Imodium together, and have interactions are studied.

What are the common drug interactions of Hydrea and Imodium, by gender? *:

female:

Oropharyngeal pain
Pain
Pain in extremity
Retching (strong involuntary effort to vomit)
Throat irritation
Blood alkaline phosphatase increased
Death
Decreased appetite
Fatigue (feeling of tiredness)
Haemoglobin decreased

male:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Haematemesis (vomiting of blood)
Sepsis (a severe blood infection that can lead to organ failure and death)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Malignant neoplasm progression (cancer tumour came back)
Blood magnesium increased
Blood phosphorus decreased
Death
Platelet count decreased

What are the common drug interactions of Hydrea and Imodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood creatine decreased
Blood lactate dehydrogenase increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypertension (high blood pressure)
Hypervolaemia (abnormally increased volume of blood)
Hypoxia (low oxygen in tissues)
International normalised ratio increased

30-39:

Cystitis (inflammation of the wall of the bladder)
Orchitis (inflammation of the testes)
Pyelonephritis (inflammation of kidney caused by bacteria)
Pyrexia (fever)
Abdominal pain
Abdominal pain upper
Decreased appetite
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Haemoglobin decreased

40-49:

Abdominal pain
Blood alkaline phosphatase increased
Cough
Dysgeusia (disorder of the sense of taste)
Dysuria (painful or difficult urination)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypokalaemia (low potassium)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Oropharyngeal pain

50-59:

Vomiting
Weight increased
Nausea (feeling of having an urge to vomit)
Anxiety
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Blood creatinine increased
Blood phosphorus decreased
Dehydration (dryness resulting from the removal of water)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

60+:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Haematemesis (vomiting of blood)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Blood magnesium increased
Blood urea increased
Sepsis (a severe blood infection that can lead to organ failure and death)
Malignant neoplasm progression (cancer tumour came back)
Blood calcium decreased
Blood phosphorus decreased

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 23 people, 31.08%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 13 people, 17.57%
Pain: 8 people, 10.81%
Headache (pain in head): 8 people, 10.81%
Oedema Peripheral (superficial swelling): 5 people, 6.76%
Nausea (feeling of having an urge to vomit): 5 people, 6.76%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 6.76%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 5.41%
Leukocytosis (increased white blood cells): 4 people, 5.41%
Diabetes: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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