Hydrea and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrea (hydroxyurea) and Lactulose (lactulose). Common drug interactions include bacterial sepsis among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrea and Lactulose. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

On Feb, 09, 2026

39 people who take Hydrea and Lactulose together, and have interactions are studied.

What are the common drug interactions of Hydrea and Lactulose, by gender? *:

female:

Bacterial sepsis
Decreased appetite
Febrile neutropenia (fever with reduced white blood cells)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)
Memory impairment
Somnolence (a state of near-sleep, a strong desire for sleep)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)

male:

Back pain
Abdominal pain upper
Actinic keratosis (skin disease due to sun exposure)
Activated partial thromboplastin time prolonged
Anxiety
Aspartate aminotransferase increased
Asthenia (weakness)
Blood culture positive
Blood glucose increased
Blood iron increased

What are the common drug interactions of Hydrea and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)
Memory impairment
Somnolence (a state of near-sleep, a strong desire for sleep)
Blood bilirubin increased
Blood lactate dehydrogenase increased
Breath sounds
Neck pain
Pain
Chest pain

50-59:

Death

60+:

Oedema peripheral (superficial swelling)
Mucosal inflammation (infection of mucous membrane)
Hypertension (high blood pressure)
Proteinuria (presence of protein in the urine)
Rash
Chronic kidney disease
Fall
Femur fracture
Haemoglobin decreased
Haemorrhagic anaemia (anaemia due to excessive bleeding)

What are the existing conditions these people have? *

Ovarian Cancer (cancer of ovary): 10 people, 25.64%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 7 people, 17.95%
Stress And Anxiety: 6 people, 15.38%
Nausea (feeling of having an urge to vomit): 5 people, 12.82%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 12.82%
Pain: 5 people, 12.82%
Muscle Aches (muscle pain): 4 people, 10.26%
Depression: 4 people, 10.26%
Flatulence (flatus expelled through the anus): 4 people, 10.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

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