Hydrochlorothiazide and Dapagliflozin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrochlorothiazide (hydrochlorothiazide) and Dapagliflozin (dapagliflozin). Common drug interactions include hyperglycaemia among females and lethargy among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrochlorothiazide and Dapagliflozin. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Dapagliflozin?

Dapagliflozin has active ingredients of dapagliflozin. eHealthMe is studying from 1,197 Dapagliflozin users. Check the latest studies of Dapagliflozin.

On Aug, 01, 2026

30 people who take Hydrochlorothiazide and Dapagliflozin together, and have interactions are studied.

Hydrochlorothiazide and Dapagliflozin drug interactions.

What are the common drug interactions of Hydrochlorothiazide and Dapagliflozin, by gender? *:

female:

Hyperglycaemia (high blood sugar)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Syncope (loss of consciousness with an inability to maintain postural tone)
Dysarthria (speech disorder)
Hyperkalaemia (damage to or disease of the kidney)
Asthenia (weakness)
Blood potassium decreased
Chronic kidney disease
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

male:

Lethargy (tiredness)
Muscular weakness (muscle weakness)
Vascular procedure complication
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Back pain
Bladder transitional cell carcinoma (types of bladder cancer)
Fungal infection
Hyperkalaemia (damage to or disease of the kidney)
Ill-defined disorder

What are the common drug interactions of Hydrochlorothiazide and Dapagliflozin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Asthenia (weakness)
Blood potassium decreased
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dizziness
Weight decreased

50-59:

Hyperglycaemia (high blood sugar)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

60+:

Lethargy (tiredness)
Muscular weakness (muscle weakness)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Dysarthria (speech disorder)
Graft infection (infection of graft site)
Vascular procedure complication
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Back pain
Bladder transitional cell carcinoma (types of bladder cancer)

What are the existing conditions these people have? *

Type 2 Diabetes: 16 people, 53.33%
Diabetes: 14 people, 46.67%
Pain: 10 people, 33.33%
Chronic Kidney Disease: 7 people, 23.33%
High Blood Cholesterol: 6 people, 20.00%
Depression: 6 people, 20.00%
Dyslipidaemia (abnormal amount of lipids): 6 people, 20.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 16.67%
Enlarged Prostate: 4 people, 13.33%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and Dapagliflozin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously