Hydrochlorothiazide and Ester c drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrochlorothiazide (hydrochlorothiazide) and Ester c (l-ascorbic acid). Common drug interactions include dizziness among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrochlorothiazide and Ester c. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Ester c?

Ester c has active ingredients of l-ascorbic acid. eHealthMe is studying from 306 Ester c users. Check the latest studies of Ester c.



On Jul, 27, 2026

11 people who take Hydrochlorothiazide and Ester c together, and have interactions are studied.

Hydrochlorothiazide and Ester c drug interactions.

What are the common drug interactions of Hydrochlorothiazide and Ester C, by gender? *:

female:

  1. Dizziness
  2. Ear infection
  3. Hypoacusis (loss of hearing)
  4. Inner ear disorder
  5. Lymphatic fistula (a leakage of lymphatic fluid from lymphatic vessel)
  6. Middle ear effusion (fluid in middle ear)
  7. Multiple allergies (allergy to multiple agents)
  8. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  9. Nasopharyngitis (inflammation of the nasopharynx)
  10. Pulmonary embolism (blockage of the main artery of the lung)

male:

  1. Chronic kidney disease
  2. Constipation
  3. Dysgeusia (disorder of the sense of taste)
  4. Eating disorder
  5. Fatigue (feeling of tiredness)
  6. Nausea (feeling of having an urge to vomit)
  7. Nephrogenic anaemia (anaemia due to kidney disease)
  8. Nephropathy (damage to or disease of a kidney)
  9. Renal failure (kidney dysfunction)
  10. Seasonal allergy (allergic condition due to certain season)

What are the common drug interactions of Hydrochlorothiazide and Ester C, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Neoplasm progression (growth of tumour)
  2. Platelet count decreased

60+:

  1. Abdominal pain
  2. Alopecia (absence of hair from areas of the body)
  3. Hair colour changes
  4. Hair disorder
  5. Hospitalisation
  6. Hypoacusis (loss of hearing)
  7. Inner ear disorder
  8. Kidney infection
  9. Lethargy (tiredness)
  10. Lymphatic fistula (a leakage of lymphatic fluid from lymphatic vessel)

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 3 people, 27.27%
  2. Urinary Tract Infection: 1 person, 9.09%
  3. Fatigue (feeling of tiredness): 1 person, 9.09%
  4. Blood Uric Acid Decreased: 1 person, 9.09%
  5. Breast Cancer: 1 person, 9.09%
  6. Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 9.09%
  7. Constipation: 1 person, 9.09%
  8. Cough: 1 person, 9.09%
  9. Dyslipidaemia (abnormal amount of lipids): 1 person, 9.09%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and Ester c?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Hydrochlorothiazide and Ester c:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ester c:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydrochlorothiazide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ester c and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide and l-ascorbic acid (the active ingredients of Hydrochlorothiazide and Ester c, respectively), and Hydrochlorothiazide and Ester c (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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