Hydrocodone bitartrate and acetaminophen and Bextra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone bitartrate and acetaminophen (acetaminophen; hydrocodone bitartrate) and Bextra (valdecoxib). Common drug interactions include tubulointerstitial nephritis among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone bitartrate and acetaminophen and Bextra. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone bitartrate and acetaminophen?

Hydrocodone bitartrate and acetaminophen has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 67,662 Hydrocodone bitartrate and acetaminophen users. Check the latest studies of Hydrocodone bitartrate and acetaminophen.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

On Jul, 09, 2026

52 people who take Hydrocodone bitartrate and acetaminophen and Bextra together, and have interactions are studied.

Hydrocodone bitartrate and acetaminophen and Bextra drug interactions.

What are the common drug interactions of Hydrocodone Bitartrate And Acetaminophen and Bextra, by gender? *:

female:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Anaemia (lack of blood)
Asthenia (weakness)
Blood triglycerides increased
Bone disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Emotional disorder
Fracture displacement
Hallucination (an experience involving the perception of something not present)

male:

Drug dependence
Depression
Dysuria (painful or difficult urination)
General physical health deterioration (weak health status)
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Intervertebral disc disorder (spinal disc disorder)
Irritability
Lethargy (tiredness)
Mood swings (an extreme or rapid change in mood)

What are the common drug interactions of Hydrocodone Bitartrate And Acetaminophen and Bextra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Gallbladder disorder
Muscle spasms (muscle contraction)
Thrombosis (formation of a blood clot inside a blood vessel)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiomegaly (increased size of heart than normal)
Cogwheel rigidity (tension in a muscle which gives way in little jerks when the muscle is stretched)

40-49:

Blood cholesterol increased
Blood triglycerides increased
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Obesity (having too much body fat)
Type 2 diabetes mellitus
Abdominal discomfort
Abdominal distension
Abdominal tenderness
Anxiety

50-59:

Restlessness (not able to rest)
Somnolence (a state of near-sleep, a strong desire for sleep)
Spinal stenosis (narrowing of spinal column)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Cataract (clouding of the lens inside the eye)
Anaemia (lack of blood)
Anxiety
Arthralgia (joint pain)

60+:

Chronic kidney disease
Depression
Hypertension (high blood pressure)
Insomnia (sleeplessness)
Intervertebral disc operation
Low turnover osteopathy (slow removal of old bone and its replacement by new bone)
Neuropathy peripheral (surface nerve damage)
Overdose
Renal failure (kidney dysfunction)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 34.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 30.77%
Back Pain: 14 people, 26.92%
Depression: 14 people, 26.92%
Hypersensitivity: 13 people, 25.00%
Osteoporosis (bones weak and more likely to break): 10 people, 19.23%
Headache (pain in head): 10 people, 19.23%
Nausea (feeling of having an urge to vomit): 9 people, 17.31%
Stress And Anxiety: 8 people, 15.38%
Cough: 8 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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