Hydrocodone bitartrate and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone bitartrate (hydrocodone bitartrate) and Zide (hydrochlorothiazide). Common drug interactions include dyspnoea among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone bitartrate and Zide. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone bitartrate?

Hydrocodone bitartrate has active ingredients of hydrocodone bitartrate. It is often used in chronic pain. eHealthMe is studying from 5,380 Hydrocodone bitartrate users. Check the latest studies of Hydrocodone bitartrate.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 20, 2026

18 people who take Hydrocodone bitartrate and Zide together, and have interactions are studied.

Hydrocodone bitartrate and Zide drug interactions.

What are the common drug interactions of Hydrocodone Bitartrate and Zide, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Seasonal allergy (allergic condition due to certain season)
Sinusitis (inflammation of sinus)
Anaesthesia
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac flutter (abnormal heart rhythm)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Fatigue (feeling of tiredness)

male:

Chronic kidney disease
Blood creatinine increased
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Tooth loss
Bone density decreased
Bone loss
Death
Glomerular filtration rate decreased
Hip arthroplasty

What are the common drug interactions of Hydrocodone Bitartrate and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood creatinine increased
Bone density decreased
Bone loss
Chronic kidney disease
Glomerular filtration rate decreased
Hip arthroplasty
Nephrolithiasis (calculi in the kidneys)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis (death of bone)
Renal impairment (severely reduced kidney function)

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Drug dependence
Dyspnoea (difficult or laboured respiration)
Overdose

60+:

Anaesthesia
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Heart rate increased
Infusion site haemorrhage (bleeding from infusion site)
Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Memory impairment
Migraine (headache)
Pruritus (severe itching of the skin)
Scar
Seasonal allergy (allergic condition due to certain season)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 4 people, 22.22%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 16.67%
Pain: 3 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 11.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.56%
Blood Pressure Abnormal: 1 person, 5.56%
Breakthrough Pain: 1 person, 5.56%
Breast Cancer Female: 1 person, 5.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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