Hydrocodone compound and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone compound (homatropine methylbromide; hydrocodone bitartrate) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include nasopharyngitis among females and erythema multiforme among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone compound and Hydramine. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone compound?

Hydrocodone compound has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 518 Hydrocodone compound users. Check the latest studies of Hydrocodone compound.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 14, 2026

21 people who take Hydrocodone compound and Hydramine together, and have interactions are studied.

Hydrocodone compound and Hydramine drug interactions.

What are the common drug interactions of Hydrocodone Compound and Hydramine, by gender? *:

female:

Nasopharyngitis (inflammation of the nasopharynx)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Infusion site erythema (reddening of the skin at infusion site)
Infusion site swelling
Bladder cancer
Dyspnoea (difficult or laboured respiration)
Infusion site rash
Abdominal tenderness
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dehydration (dryness resulting from the removal of water)

male:

Erythema multiforme (a type of hypersensitivity reaction)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Hydrocodone Compound and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Erythema multiforme (a type of hypersensitivity reaction)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)

50-59:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dehydration (dryness resulting from the removal of water)
Frequent bowel movements
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Leukopenia (less number of white blood cells in blood)
Nasal disorder (diseases of nose)
Neutropenia (an abnormally low number of neutrophils)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombocytopenia (decrease of platelets in blood)

60+:

Asthenia (weakness)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Colon cancer
Malaise (a feeling of general discomfort or uneasiness)
Neuropathy peripheral (surface nerve damage)
Weight decreased
Dyspnoea (difficult or laboured respiration)
Bladder cancer
Sinusitis (inflammation of sinus)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 11 people, 52.38%
Lung Cancer - Non-Small Cell (lung cancer): 5 people, 23.81%
Joint Pain: 5 people, 23.81%
Cough: 5 people, 23.81%
Bone Marrow Conditioning Regimen: 3 people, 14.29%
Viraemia (presence of a virus in the blood stream): 2 people, 9.52%
B-Cell Unclassifiable Lymphoma High Grade (rapidly progressing unclassifiable b-cell cancer difficult to treat- high grade): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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