Hydrocodone and Belsomra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen) and Belsomra (suvorexant). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone and Belsomra. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Belsomra?

Belsomra has active ingredients of suvorexant. It is often used in insomnia. eHealthMe is studying from 12,961 Belsomra users. Check the latest studies of Belsomra.

On Jul, 09, 2026

14 people who take Hydrocodone and Belsomra together, and have interactions are studied.

Hydrocodone and Belsomra drug interactions.

What are the common drug interactions of Hydrocodone and Belsomra, by gender? *:

female:

Chronic kidney disease
Abscess limb (limb infection)
Anal abscess
Cellulitis (infection under the skin)
Dizziness
Drug ineffective
Genital abscess (build up of pus in genital)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Panic attack
Perirectal abscess

male:

Chronic kidney disease
Anxiety
Heart rate increased
Hypertension (high blood pressure)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Nocturia (the need to get up in the night to urinate)
Palpitations (feelings or sensations that your heart is pounding or racing)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Sedation

What are the common drug interactions of Hydrocodone and Belsomra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Dizziness

50-59:

Chronic kidney disease
Heart rate increased
Hypertension (high blood pressure)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nocturia (the need to get up in the night to urinate)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Panic attack
Perirectal abscess

60+:

Drug ineffective

What are the existing conditions these people have? *

Pain: 5 people, 35.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 28.57%
High Blood Cholesterol: 4 people, 28.57%
Quit Smoking: 3 people, 21.43%
Bacterial Infection: 3 people, 21.43%
Depression: 3 people, 21.43%
Type 2 Diabetes: 3 people, 21.43%
Nausea (feeling of having an urge to vomit): 3 people, 21.43%
High Blood Pressure: 3 people, 21.43%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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