Hydrocodone and Cabometyx drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen) and Cabometyx (cabozantinib s-malate). Common drug interactions include oral mucosal blistering among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone and Cabometyx. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Cabometyx?

Cabometyx has active ingredients of cabozantinib s-malate. eHealthMe is studying from 35,069 Cabometyx users. Check the latest studies of Cabometyx.

On Jul, 14, 2026

85 people who take Hydrocodone and Cabometyx together, and have interactions are studied.

Hydrocodone and Cabometyx drug interactions.

What are the common drug interactions of Hydrocodone and Cabometyx, by gender? *:

female:

Oral mucosal blistering (mouth ulcer)
Thrombotic stroke (stroke due to clot formation)
Thyroid disorder (thyroid diseases)
Tongue blistering
Constipation
Weight decreased
Dry skin
Diarrhoea
Stomatitis (inflammation of mucous membrane of mouth)
Acne (skin problems that cause pimples)

male:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Weight decreased
Dizziness
Back pain
Abdominal pain upper
Dry mouth
Headache (pain in head)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Glossodynia (a burning or painful sensation in the tongue)

What are the common drug interactions of Hydrocodone and Cabometyx, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood iron decreased
Blood pressure increased
Diarrhoea
Food intolerance (inability to have food)
Nasal ulcer (ulcer of nose)
Nausea (feeling of having an urge to vomit)
Pneumonia
Blood calcium decreased
Blood magnesium decreased
Blood pressure decreased

40-49:

Acne (skin problems that cause pimples)
Blood pressure fluctuation
Constipation
Drug ineffective
Erythema (redness of the skin)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Skin discolouration (change of skin colour)

50-59:

Radiation associated pain (pain due to radiation)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure increased
Bone disorder
Dizziness
Fall
Femoral nerve injury
Headache (pain in head)
Hemiparesis (weakness on one side of the body)
Malignant neoplasm progression (cancer tumour came back)

60+:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Malaise (a feeling of general discomfort or uneasiness)
Dizziness
Dysphonia (speech disorder attributable to a disorder of phonation)
Pain
Pain in extremity
Arthralgia (joint pain)
Dysphagia (a condition in which swallowing is difficult or painful)
Stomatitis (inflammation of mucous membrane of mouth)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 74 people, 87.06%
Metastases To Bone (cancer spreads to bone): 5 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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