Hydrocodone and Relafen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocodone (hydrocodone bitartrate; ibuprofen) and Relafen (nabumetone). Common drug interactions include dysphagia among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocodone and Relafen. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

What is Relafen?

Relafen has active ingredients of nabumetone. It is often used in arthritis. eHealthMe is studying from 6,243 Relafen users. Check the latest studies of Relafen.

On Jul, 19, 2026

13 people who take Hydrocodone and Relafen together, and have interactions are studied.

Hydrocodone and Relafen drug interactions.

What are the common drug interactions of Hydrocodone and Relafen, by gender? *:

female:

Dysphagia (a condition in which swallowing is difficult or painful)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)
Lumbar vertebral fracture
Malaise (a feeling of general discomfort or uneasiness)
Meningoencephalitis herpetic (inflammation of the brain and meninges by virus)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)

male:

Chest pain
Drug abuser
Antisocial behaviour
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Blindness
Blood pressure fluctuation
Blood sodium increased

What are the common drug interactions of Hydrocodone and Relafen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Chest pain
Confusional state
Constipation
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug abuser
Drug dependence
Dysphagia (a condition in which swallowing is difficult or painful)
Hepatomegaly (abnormal enlargement of the liver)
Memory impairment

40-49:

Pharyngolaryngeal pain
Polysubstance abuse
Post-traumatic stress disorder
Psychiatric symptom
Psychomotor hyperactivity (feelings of extreme restlessness)
Psychotic disorder
Rhinorrhoea (watery mucus discharge from the nose)
Road traffic accident
Sedation
Self injurious behaviour

50-59:

Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
Chest discomfort
Chest pain
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperhidrosis (abnormally increased sweating)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Back pain
Cryptogenic organizing pneumonia (small airways (bronchioles) and air exchange sac (alveoli) become inflamed with connective tissue)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Colitis ulcerative (inflammation of colon with ulcer)
Confusional state
Dysphagia (a condition in which swallowing is difficult or painful)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)
Lumbar vertebral fracture

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 38.46%
Pain: 5 people, 38.46%
High Blood Pressure: 4 people, 30.77%
Depression: 3 people, 23.08%
Multiple Allergies (allergy to multiple agents): 3 people, 23.08%
Insomnia (sleeplessness): 3 people, 23.08%
Indigestion: 2 people, 15.38%
Hyperkalemia (damage to or disease of the kidney): 2 people, 15.38%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 15.38%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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