Hydrocortisone and Acetazolamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocortisone (hydrocortisone) and Acetazolamide (acetazolamide). Common drug interactions include collapse among females and pulmonary oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocortisone and Acetazolamide. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

What is Acetazolamide?

Acetazolamide has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 6,178 Acetazolamide users. Check the latest studies of Acetazolamide.

On Jul, 14, 2026

68 people who take Hydrocortisone and Acetazolamide together, and have interactions are studied.

Hydrocortisone and Acetazolamide drug interactions.

What are the common drug interactions of Hydrocortisone and Acetazolamide, by gender? *:

female:

Collapse (sudden functional breakdown)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Haemoglobin decreased
Septic shock (shock due to blood infection)
White blood cell count increased
Blood creatine phosphokinase increased
Depressed level of consciousness
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Fatigue (feeling of tiredness)
Headache (pain in head)

male:

Pulmonary oedema (fluid accumulation in the lungs)
Dyspnoea (difficult or laboured respiration)
Cardiomegaly (increased size of heart than normal)
Cardiorenal syndrome (kidney failure and heart failure)
Confusional state
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Gangrene (body tissue dies)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Hypotension (abnormally low blood pressure)
Melaena (the passage of black, tarry stools)

What are the common drug interactions of Hydrocortisone and Acetazolamide, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

Vomiting
Drug level increased
Face oedema (swelling of face)
Renal failure acute (rapid kidney dysfunction)
Altered state of consciousness (altered state of mind)
Ascites (accumulation of fluid in the abdominal cavity)
Blood alkaline phosphatase increased
Blood lactate dehydrogenase increased
Epistaxis (bleed from the nose)
Eyelid oedema (eyelids are swollen and contain excessive fluid)

10-19:

Bacterial infection
Peripheral sensorimotor neuropathy (damage to one or more of your peripheral nerves)
Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
Pulmonary oedema (fluid accumulation in the lungs)
Cerebral haemorrhage (bleeding within the brain)
Drug ineffective
Pancreatitis (inflammation of pancreas)
Coagulopathy (blood's ability to clot is impaired)
Hyperglycaemia (high blood sugar)
Hypersensitivity

20-29:

Influenza like illness
Pyrexia (fever)
Cardiac arrest
Collapse (sudden functional breakdown)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Haemoglobin decreased
Multi-organ failure (multisystem organ failure)
White blood cell count increased
Blood creatine phosphokinase increased
Depressed level of consciousness

30-39:

Bradycardia (abnormally slow heart action)
Cardiac death
Hyperkalaemia (damage to or disease of the kidney)
Ventricular fibrillation (abnormally irregular heart rhythm)
Drug ineffective
Hypotension (abnormally low blood pressure)
Lethargy (tiredness)
Septic shock (shock due to blood infection)

40-49:

Benign breast neoplasm (benign (non-cancerous) tumours of the breast)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Depression
Hospitalisation
Hypersomnia (excessive daytime sleepiness (eds))
Lumbar radiculopathy (radicular pain in the low back and legs)
Migraine (headache)
Renal failure (kidney dysfunction)
Hypotension (abnormally low blood pressure)
Pain

50-59:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Thrombotic thrombocytopenic purpura (a rare blood disorder characterized by clotting in small blood vessels of the body)
Vomiting
Acute respiratory failure
Anaemia (lack of blood)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiomegaly (increased size of heart than normal)
Cardiorenal syndrome (kidney failure and heart failure)
Confusional state

60+:

Dyspnoea (difficult or laboured respiration)
International normalised ratio increased
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bradycardia (abnormally slow heart action)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardioactive drug level increased
Chest pain
Conjunctival hyperaemia (congestion of conjunctival vessels)
Cough

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 9 people, 13.24%
Pain: 7 people, 10.29%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 6 people, 8.82%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 5 people, 7.35%
Respiratory Disorder (respiratory disease): 5 people, 7.35%
Constipation: 5 people, 7.35%
Anaesthesia: 5 people, 7.35%
Stress And Anxiety: 4 people, 5.88%
Indigestion: 4 people, 5.88%
High Blood Pressure: 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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