Hydrocortisone and Letairis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocortisone (hydrocortisone) and Letairis (ambrisentan). Common drug interactions include death among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocortisone and Letairis. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

What is Letairis?

Letairis has active ingredients of ambrisentan. It is often used in pulmonary hypertension. eHealthMe is studying from 94,041 Letairis users. Check the latest studies of Letairis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

37 people who take Hydrocortisone and Letairis together, and have interactions are studied.

Hydrocortisone and Letairis drug interactions.

What are the common drug interactions of Hydrocortisone and Letairis, by gender? *:

female:

Death
Dehydration (dryness resulting from the removal of water)
Dizziness
Anaemia (lack of blood)
Pneumonia
Pregnancy
Renal failure acute (rapid kidney dysfunction)
Acute respiratory failure
Cardiac infection (an infection of the heart)
Depression

male:

Death
Dyspnoea (difficult or laboured respiration)
Infusion related reaction
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oropharyngeal pain
Pneumonia
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Hydrocortisone and Letairis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pregnancy

30-39:

n/a

40-49:

Hypotension (abnormally low blood pressure)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

50-59:

Abnormal sleep-related event
Agitation (state of anxiety or nervous excitement)
Chronic kidney disease
Depression
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Emotional distress
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hallucination (an experience involving the perception of something not present)
Ligament rupture (tear in ligament)
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)

60+:

Dehydration (dryness resulting from the removal of water)
Death
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Visual impairment
Acute respiratory failure
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Chest pain
Clostridium difficile sepsis (infection(pus formation) of colon by clostridium difficile bacteria)
Cough

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 27 people, 72.97%

* Approximation only. Some reports may have incomplete information.

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