Hydrocortone and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydrocortone (hydrocortisone acetate) and Ibu (ibuprofen). Common drug interactions include hyponatraemia among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Hydrocortone and Ibu. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Hydrocortone?

Hydrocortone has active ingredients of hydrocortisone acetate. It is often used in pain. eHealthMe is studying from 912 Hydrocortone users. Check the latest studies of Hydrocortone.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

On Jul, 14, 2026

15 people who take Hydrocortone and Ibu together, and have interactions are studied.

What are the common drug interactions of Hydrocortone and Ibu, by gender? *:

female:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Infection
Irritable bowel syndrome
Medical device complication
Mobility decreased (ability to move is reduced)
Oedema peripheral (superficial swelling)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash erythematous (redness of the skin)
Rash pruritic (redness with itching)

male:

Confusional state
Delusion (a false belief or opinion)
Nausea (feeling of having an urge to vomit)
Pseudomonal bacteraemia (p. aeruginosa cause of bacterial infections of the blood)
Retching (strong involuntary effort to vomit)
Tracheobronchitis (an inflammation or infection, which affects the trachea and bronchi of respiratory tract)
Upper limb fracture
Anaemia (lack of blood)
Bacterial infection
Central line infection (infection by central line in icu)

What are the common drug interactions of Hydrocortone and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Oxygen saturation decreased
Piloerection (goose bumps)
Respiratory rate increased (excess breathing rate/min)
Staphylococcal infection (an infection with staphylococcus bacteria)
Tracheitis (an inflammation of the trachea)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Band neutrophil percentage decreased
Blood glucose increased
Blood immunoglobulin g decreased

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Abdominal distension
Abdominal pain lower
Arteritis (inflammation of the walls of arteries)
Arthralgia (joint pain)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Arthropathy
Bone loss
Bone pain
Chills (felling of cold)

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Blood amylase increased
Blood potassium increased
Blood sodium decreased
Cellulitis (infection under the skin)
Circulatory collapse
Dehydration (dryness resulting from the removal of water)

60+:

Confusional state
Delusion (a false belief or opinion)
Escherichia sepsis (bacterial infection by escherichia coli)
Haematuria (presence of blood in urine)
Haemoglobin decreased
Pelvic pain
Psychomotor retardation (motor mental retardation)
Rapid correction of hyponatraemia (rapid correction of abnormally low concentrations of sodium ions in the circulating blood)
Staphylococcal bacteraemia (a bacterial infection of blood)
Urinary tract infection bacterial

What are the existing conditions these people have? *

Herpes Zoster: 5 people, 33.33%
Neuralgia (pain in one or more nerves): 4 people, 26.67%
Inappropriate Antidiuretic Hormone Secretion: 2 people, 13.33%
Anaemia (lack of blood): 2 people, 13.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%
Prostate Cancer Metastatic: 1 person, 6.67%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 6.67%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 6.67%
Hepatitis C: 1 person, 6.67%
Adrenal Disorder: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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