Hydroxyurea and Centrum drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea (hydroxyurea) and Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include bronchitis among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyurea and Centrum. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.



On Jul, 07, 2026

100 people who take Hydroxyurea and Centrum together, and have interactions are studied.

Hydroxyurea and Centrum drug interactions.

What are the common drug interactions of Hydroxyurea and Centrum, by gender? *:

female:

  1. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  2. Decreased appetite
  3. Drug ineffective
  4. Dyspepsia (indigestion)
  5. Eructation (release of gas from the digestive tract)
  6. Essential thrombocythaemia (chronic blood cancer)
  7. Fall
  8. Neoplasm malignant (cancer tumour)
  9. Oesophageal discomfort (pain or burning feeling behind breast bone)
  10. Retinal haemorrhage (bleeding from retina)

male:

  1. Abdominal discomfort
  2. Dyspepsia (indigestion)
  3. Asthenia (weakness)
  4. Haemoglobin decreased
  5. Infection
  6. Arthralgia (joint pain)
  7. Back pain
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  9. Death
  10. Decreased appetite

What are the common drug interactions of Hydroxyurea and Centrum, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Arthralgia (joint pain)
  2. Arthropathy
  3. Deformity (disfigurement)
  4. Joint stiffness

20-29:

  1. Headache (pain in head)

30-39:

n/a

40-49:

  1. Anaphylactic reaction (serious allergic reaction)
  2. Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
  3. Dyspnoea (difficult or laboured respiration)
  4. Jaw disorder (jaw disease)
  5. Rigors (an episode of shaking or exaggerated shivering)

50-59:

n/a

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Asthenia (weakness)
  3. Oesophageal discomfort (pain or burning feeling behind breast bone)
  4. Anaemia (lack of blood)
  5. Dehydration (dryness resulting from the removal of water)
  6. Disease progression
  7. Vomiting
  8. Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
  9. Contusion (a type of hematoma of tissue in which capillaries)
  10. Decreased appetite

What are the existing conditions these people have? *

  1. Primary Myelofibrosis (primary disorder of the bone marrow): 21 people, 21.00%
  2. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 13 people, 13.00%
  3. Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyurea and Centrum?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Hydroxyurea and Centrum:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydroxyurea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Centrum:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydroxyurea and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Centrum and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyurea and ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Hydroxyurea and Centrum, respectively), and Hydroxyurea and Centrum (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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