Hydroxyurea and Pioglitazone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea (hydroxyurea) and Pioglitazone (pioglitazone hydrochloride). Common drug interactions include aortic thrombosis among females and subdural haematoma among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyurea and Pioglitazone. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

On Jul, 26, 2026

17 people who take Hydroxyurea and Pioglitazone together, and have interactions are studied.

Hydroxyurea and Pioglitazone drug interactions.

What are the common drug interactions of Hydroxyurea and Pioglitazone, by gender? *:

female:

Aortic thrombosis (formation of a blood clot inside aorta)
Post procedural haematoma (post procedural clotting of blood)
Splenic infarction (tissue damage of spleen)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haematochezia (passage of stools containing blood)
Hepatic mass
Leukaemia (blood or bone marrow cancer)
Muscle spasms (muscle contraction)
Pain in extremity
Thrombocytopenia (decrease of platelets in blood)

male:

Subdural haematoma (blood collects between the skull and the surface of the brain)
Asthenia (weakness)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Thrombocytopenia (decrease of platelets in blood)
Cerebral haematoma (collection of blood in brain)
Headache (pain in head)
Rib fracture
Skull fracture
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)
Anisocytosis (patient's red blood cells are of unequal size)

What are the common drug interactions of Hydroxyurea and Pioglitazone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Subdural haematoma (blood collects between the skull and the surface of the brain)
Asthenia (weakness)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Thrombocytopenia (decrease of platelets in blood)
Cerebral haematoma (collection of blood in brain)
Headache (pain in head)
Rib fracture
Skull fracture
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)
Anisocytosis (patient's red blood cells are of unequal size)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 41.18%
High Blood Pressure: 6 people, 35.29%
Indigestion: 3 people, 17.65%
Pain: 3 people, 17.65%
Essential Thrombocythaemia (chronic blood cancer): 3 people, 17.65%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 11.76%
High Blood Cholesterol: 2 people, 11.76%
Constipation: 2 people, 11.76%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 11.76%
Insomnia (sleeplessness): 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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