Hydroxyurea and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea (hydroxyurea) and Reglan (metoclopramide hydrochloride). Common drug interactions include infusion site irritation among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyurea and Reglan. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

On Jul, 11, 2026

41 people who take Hydroxyurea and Reglan together, and have interactions are studied.

Hydroxyurea and Reglan drug interactions.

What are the common drug interactions of Hydroxyurea and Reglan, by gender? *:

female:

Infusion site irritation
Joint swelling
Vomiting
Death
Chest pain
Dyspnoea (difficult or laboured respiration)
Haemoglobin decreased
Headache (pain in head)
Pain
Platelet count decreased

male:

Hypotension (abnormally low blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Pneumonia
Respiratory distress (difficulty in breathing)
Sepsis (a severe blood infection that can lead to organ failure and death)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Death
Disease progression

What are the common drug interactions of Hydroxyurea and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Death

20-29:

n/a

30-39:

Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)

40-49:

Chest pain
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Haemoglobin decreased
Hospitalisation
Influenza
Pain
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Platelet count decreased

50-59:

Alopecia (absence of hair from areas of the body)
Hypotension (abnormally low blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Hair colour changes
Hair disorder
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Atelectasis (partial or complete collapse of the lung)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

60+:

Diarrhoea
Abdominal discomfort
Haemoglobin decreased
Malaise (a feeling of general discomfort or uneasiness)
Pain
Periorbital oedema (swelling around the eyes)
Platelet count decreased
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Skin burning sensation

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 19.51%
Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 5 people, 12.20%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 12.20%
Breast Cancer Female: 4 people, 9.76%
Pain: 3 people, 7.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.32%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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