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Hydroxyurea and Tapentadol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyurea (hydroxyurea) and Tapentadol (tapentadol). Common drug interactions include skin lesion among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyurea and Tapentadol. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

What is Tapentadol?

Tapentadol has active ingredients of tapentadol. It is often used in chronic pain. eHealthMe is studying from 2,551 Tapentadol users. Check the latest studies of Tapentadol.

On Jul, 11, 2026

18 people who take Hydroxyurea and Tapentadol together, and have interactions are studied.

Hydroxyurea and Tapentadol drug interactions.

What are the common drug interactions of Hydroxyurea and Tapentadol, by gender? *:

female:

  1. Skin lesion
  2. Dehydration (dryness resulting from the removal of water)
  3. Nausea (feeling of having an urge to vomit)
  4. Vomiting

male:

  1. Pyrexia (fever)
  2. Febrile neutropenia (fever with reduced white blood cells)

What are the common drug interactions of Hydroxyurea and Tapentadol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Skin lesion

40-49:

n/a

50-59:

  1. Dehydration (dryness resulting from the removal of water)
  2. Nausea (feeling of having an urge to vomit)
  3. Vomiting

60+:

  1. Pyrexia (fever)
  2. Febrile neutropenia (fever with reduced white blood cells)

What are the existing conditions these people have? *

  1. Pain: 10 people, 55.56%
  2. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 9 people, 50.00%
  3. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 50.00%
  4. Leukocytosis (increased white blood cells): 9 people, 50.00%
  5. Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 9 people, 50.00%
  6. Pleural Effusion (water on the lungs): 9 people, 50.00%
  7. Inflammation: 8 people, 44.44%
  8. Bacterial Infection: 8 people, 44.44%
  9. High Blood Pressure: 6 people, 33.33%
  10. Primary Myelofibrosis (primary disorder of the bone marrow): 6 people, 33.33%

* Approximation only. Some reports may have incomplete information.

Do you take Hydroxyurea and Tapentadol?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Hydroxyurea and Tapentadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydroxyurea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tapentadol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydroxyurea and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tapentadol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydroxyurea and tapentadol (the active ingredients of Hydroxyurea and Tapentadol, respectively), and Hydroxyurea and Tapentadol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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