Hydroxyzine hydrochloride and Ofev drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine hydrochloride (hydroxyzine hydrochloride) and Ofev (nintedanib esylate). Common drug interactions include diarrhoea among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine hydrochloride and Ofev. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine hydrochloride?

Hydroxyzine hydrochloride has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 10,486 Hydroxyzine hydrochloride users. Check the latest studies of Hydroxyzine hydrochloride.

What is Ofev?

Ofev has active ingredients of nintedanib esylate. eHealthMe is studying from 24,791 Ofev users. Check the latest studies of Ofev.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 03, 2026

16 people who take Hydroxyzine hydrochloride and Ofev together, and have interactions are studied.

Hydroxyzine hydrochloride and Ofev drug interactions.

What are the common drug interactions of Hydroxyzine Hydrochloride and Ofev, by gender? *:

female:

  1. Diarrhoea
  2. Chest pain
  3. Pain
  4. Back pain
  5. Dizziness
  6. Dry mouth
  7. Nausea (feeling of having an urge to vomit)
  8. Vomiting
  9. Cough
  10. Oropharyngeal discomfort (pain or irritation of oropharynx)

male:

  1. Dyspnoea (difficult or laboured respiration)
  2. Nausea (feeling of having an urge to vomit)
  3. Hypoaesthesia (reduced sense of touch or sensation)
  4. Infusion related reaction
  5. Injection site erythema (redness at injection site)
  6. Injection site oedema
  7. Interstitial lung disease
  8. Productive cough
  9. Diarrhoea
  10. Disease progression

What are the common drug interactions of Hydroxyzine Hydrochloride and Ofev, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Dyspnoea (difficult or laboured respiration)
  2. Nausea (feeling of having an urge to vomit)
  3. Headache (pain in head)
  4. Hypoaesthesia (reduced sense of touch or sensation)
  5. Infusion related reaction
  6. Injection site erythema (redness at injection site)
  7. Injection site oedema
  8. Interstitial lung disease
  9. Productive cough
  10. Back pain

What are the existing conditions these people have? *

  1. Idiopathic Pulmonary Fibrosis (chronic lung disease): 11 people, 68.75%
  2. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 25.00%
  3. Immunodeficiency Common Variable: 4 people, 25.00%
  4. Immunodeficiency: 3 people, 18.75%
  5. Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 18.75%
  6. Connective Tissue Disorder (any disease that has the connective tissues of the body): 3 people, 18.75%
  7. Immune System Disorder: 2 people, 12.50%
  8. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Hydroxyzine hydrochloride and Ofev:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydroxyzine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ofev:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydroxyzine hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ofev and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on hydroxyzine hydrochloride and nintedanib esylate (the active ingredients of Hydroxyzine hydrochloride and Ofev, respectively), and Hydroxyzine hydrochloride and Ofev (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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