Hydroxyzine hydrochloride and Rinvoq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine hydrochloride (hydroxyzine hydrochloride) and Rinvoq (upadacitinib). Common drug interactions include rash among females and dermatitis atopic among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine hydrochloride and Rinvoq. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine hydrochloride?

Hydroxyzine hydrochloride has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 10,486 Hydroxyzine hydrochloride users. Check the latest studies of Hydroxyzine hydrochloride.

What is Rinvoq?

Rinvoq has active ingredients of upadacitinib. eHealthMe is studying from 47,375 Rinvoq users. Check the latest studies of Rinvoq.

On Jul, 12, 2026

46 people who take Hydroxyzine hydrochloride and Rinvoq together, and have interactions are studied.

Hydroxyzine hydrochloride and Rinvoq drug interactions.

What are the common drug interactions of Hydroxyzine Hydrochloride and Rinvoq, by gender? *:

female:

Rash
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Nausea (feeling of having an urge to vomit)
Staphylococcal infection (an infection with staphylococcus bacteria)
Swelling
Ankylosing spondylitis (type of arthritis affecting the spine)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Feeling hot

male:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Hepatic enzyme increased
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Limb injury
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Rash papular (redness with papule)

What are the common drug interactions of Hydroxyzine Hydrochloride and Rinvoq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Discomfort
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Haemarthrosis (haemarthrosis is where blood is able to enter the joint capsule)
Rash

20-29:

Staphylococcal infection (an infection with staphylococcus bacteria)
Adverse drug reaction
Cellulitis (infection under the skin)
Drug tolerance decreased
Hospitalisation

30-39:

Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Rash papular (redness with papule)

40-49:

Drug ineffective

50-59:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Diarrhoea
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Ludwig angina (a type of cellulitis that involves the floor of the mouth, under the tongue)
Nausea (feeling of having an urge to vomit)
Pain

60+:

Acute myocardial infarction (acute heart attack)
Blood cholesterol increased
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Blood creatine phosphokinase increased
Blood triglycerides increased
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Drug ineffective
Injection site bruising
Liver disorder (liver diseases)
Pneumonia

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 21 people, 45.65%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 17 people, 36.96%

* Approximation only. Some reports may have incomplete information.

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