Hydroxyzine and Augmentin '125' drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Augmentin '125' (amoxicillin; clavulanate potassium). Common drug interactions include diverticulum among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Augmentin '125'. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Augmentin '125'?

Augmentin '125' has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 10,452 Augmentin '125' users. Check the latest studies of Augmentin '125'.

On Jul, 08, 2026

38 people who take Hydroxyzine and Augmentin '125' together, and have interactions are studied.

Hydroxyzine and Augmentin '125' drug interactions.

What are the common drug interactions of Hydroxyzine and Augmentin '125', by gender? *:

female:

Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Eye pain
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Oedema peripheral (superficial swelling)
Oropharyngeal pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Spinal osteoarthritis (joint cartilage loss in spine)
Asthenia (weakness)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Dyspnoea (difficult or laboured respiration)

male:

Asthenia (weakness)
Emotional distress
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Pulmonary hypertension (increase in blood pressure in the lung artery)
Tricuspid valve incompetence (inefficient heart valve)
Vomiting
Abdominal pain
Aortic arteriosclerosis (hardening of the aortic arteries)

What are the common drug interactions of Hydroxyzine and Augmentin '125', by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Maternal exposure during pregnancy (use of substance during pregnancy)
Polyhydramnios (excess of amniotic fluid in the amniotic sac)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Liver injury
Upper respiratory tract infection

40-49:

Conjunctivitis (pink eye)
Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
Death
Drug hypersensitivity
Exfoliative rash (scaly red generalized skin rash)
Hepatitis (inflammation of the liver)
Pruritus generalised (generalized itching)
Skin hyperpigmentation (disorders affect the colour of your skin)
Swelling face
Type 2 diabetes mellitus

50-59:

Blood creatinine increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Dyspnoea (difficult or laboured respiration)
Generalised oedema (swelling all over the body)
Lung neoplasm malignant (cancer tumour of lung)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose
Type 2 diabetes mellitus
Blood pressure increased

60+:

Asthenia (weakness)
Emotional distress
Osteonecrosis of jaw (death of bone of jaw)
Tooth abscess (pus formation in tooth)
Anaemia (lack of blood)
Chest pain
Hyperlipidaemia (presence of excess lipids in the blood)
Oropharyngeal pain
Pyrexia (fever)
Abdominal pain

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 36.84%
High Blood Pressure: 5 people, 13.16%
Depression: 4 people, 10.53%
Nausea (feeling of having an urge to vomit): 4 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.53%
Insomnia (sleeplessness): 4 people, 10.53%
Oedema (fluid collection in tissue): 3 people, 7.89%
Hypersensitivity: 3 people, 7.89%
Sleep Disorder: 2 people, 5.26%
Herpes Zoster: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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