Hydroxyzine and Divigel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Divigel (estradiol). Common drug interactions include injection site pain among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Divigel. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Divigel?

Divigel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 894 Divigel users. Check the latest studies of Divigel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

18 people who take Hydroxyzine and Divigel together, and have interactions are studied.

Hydroxyzine and Divigel drug interactions.

What are the common drug interactions of Hydroxyzine and Divigel, by gender? *:

female:

Injection site pain
Nausea (feeling of having an urge to vomit)
Vomiting
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood iron decreased
Borderline personality disorder
Breast cancer
Breast cancer metastatic
Confusional state

male:

Completed suicide (act of taking one's own life)

What are the common drug interactions of Hydroxyzine and Divigel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Completed suicide (act of taking one's own life)

40-49:

Arthritis (form of joint disorder that involves inflammation of one or more joints)

50-59:

Escherichia infection (bacterial infection by escherichia coli)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Arthralgia (joint pain)
Blood iron decreased
Confusional state
Depressed mood
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Fall
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Ear infection
Hypoacusis (loss of hearing)
Nausea (feeling of having an urge to vomit)
Breast cancer
Breast cancer metastatic
Memory impairment
Vomiting

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 22.22%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 22.22%
Asthma: 3 people, 16.67%
Insomnia (sleeplessness): 2 people, 11.11%
Hypersensitivity: 2 people, 11.11%
High Blood Pressure: 2 people, 11.11%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.56%
Nausea And Vomiting: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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