Hydroxyzine and Fiorinal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Fiorinal (aspirin; butalbital; caffeine). Common drug interactions include emotional distress among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Fiorinal. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

On Jul, 30, 2026

43 people who take Hydroxyzine and Fiorinal together, and have interactions are studied.

Hydroxyzine and Fiorinal drug interactions.

What are the common drug interactions of Hydroxyzine and Fiorinal, by gender? *:

female:

Emotional distress
Glomerular filtration rate increased
Muscular weakness (muscle weakness)
Sinusitis (inflammation of sinus)
Suicidal ideation
Suicide attempt
Urinary tract infection
Bankruptcy
Compulsive hoarding (unwillingness to discard large quantities of objects that cover the living areas)
Compulsive sexual behaviour (unable to manage his/her sexual behaviour)

male:

Abdominal discomfort
Abdominal distension
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Cerebral atrophy (decrement in size of brain)
Cerebral disorder (brain disease)
Cervical cord compression (compression of spinal cord at site of cervical vertebrae)
Cervical myelopathy (clinical syndrome characterized by clumsiness in hands; gait imbalance; caused by compression of the spinal cord)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chest pain
Constipation

What are the common drug interactions of Hydroxyzine and Fiorinal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dizziness
Nausea (feeling of having an urge to vomit)
Vomiting
Aspartate aminotransferase increased
Asthenia (weakness)
Balance disorder
Blood oestrogen decreased
C-reactive protein increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest discomfort

30-39:

Alcoholic hangover
Asthenia (weakness)
Diplopia (double vision)
Drug ineffective
Dysarthria (speech disorder)
Euphoric mood (excessively happy but may become angry or irritable)
Feeling drunk
Haemoglobin decreased
Sedation
Speech disorder

40-49:

Nausea (feeling of having an urge to vomit)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Breast lump (localized swelling that feels different from the surrounding breast tissue)
Cardiac arrest
Cardiac failure congestive
Cardiac tamponade (fluid accumulates in heart covering)
Drug effect decreased
Dry mouth
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)

50-59:

Dizziness
Folliculitis (infection of hair root)
Impaired work ability
Influenza
Muscle spasms (muscle contraction)
Nervousness
Post-traumatic stress disorder
Tooth extraction
Urinary tract infection
Blood potassium decreased

60+:

Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Chest pain
Constipation
Depression
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 12 people, 27.91%
Pain: 5 people, 11.63%
High Blood Pressure: 5 people, 11.63%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 9.30%
Insomnia (sleeplessness): 4 people, 9.30%
Muscle Spasms (muscle contraction): 3 people, 6.98%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.98%
Depression: 3 people, 6.98%
Bladder Disorder: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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