Hydroxyzine and Kytril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Kytril (granisetron hydrochloride). Common drug interactions include abdominal distension among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Kytril. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Kytril?

Kytril has active ingredients of granisetron hydrochloride. eHealthMe is studying from 10,766 Kytril users. Check the latest studies of Kytril.

On Jul, 05, 2026

41 people who take Hydroxyzine and Kytril together, and have interactions are studied.

Hydroxyzine and Kytril drug interactions.

What are the common drug interactions of Hydroxyzine and Kytril, by gender? *:

female:

Abdominal distension
Abdominal mass (localized enlargement or swelling in the human abdomen)
Abscess intestinal (collections of pus-intestinal)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Anaemia (lack of blood)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic valve incompetence
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)

male:

Pneumonia
Anaemia (lack of blood)
Respiratory failure (inadequate gas exchange by the respiratory system)
Excessive eye blinking (excessive blinking is dry eyes)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Pain in extremity
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Arthralgia (joint pain)
Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Cough

What are the common drug interactions of Hydroxyzine and Kytril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Excessive eye blinking (excessive blinking is dry eyes)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups)
Cerebral hypoperfusion (a condition in which the brain doesn't get enough blood)
Encephalitis (inflammation of the brain)
Hydrocephalus (water on the brain)
Hypokalaemia (low potassium)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Lipase increased
Respiratory failure (inadequate gas exchange by the respiratory system)

10-19:

Pain in extremity
Pain
Cardiac arrest
Chest pain
Chloroma (green-coloured tumour)
Cough
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Depressed level of consciousness
Drug ineffective
Dyspnoea (difficult or laboured respiration)

20-29:

Febrile neutropenia (fever with reduced white blood cells)
Thrombocytopenia (decrease of platelets in blood)
Epistaxis (bleed from the nose)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Tension headache

30-39:

n/a

40-49:

Abdominal pain
Bladder disorder
Infection
Necrosis (the death of body tissue)
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory failure (inadequate gas exchange by the respiratory system)
Ulcer

50-59:

Alopecia (absence of hair from areas of the body)
Psychological trauma
Bladder transitional cell carcinoma (types of bladder cancer)
Insulin resistant diabetes
Pancreatic carcinoma (pancreatic cancer)
Pancreatitis (inflammation of pancreas)

60+:

Asthenia (weakness)
Pneumonia
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic valve incompetence
Arrhythmia (irregular heartbeat)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
B-cell lymphoma (blood cancer affecting b cells)
Back pain
Beta 2 microglobulin increased

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 12 people, 29.27%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 11 people, 26.83%
Nausea And Vomiting: 8 people, 19.51%
Pain: 7 people, 17.07%
Flatulence (flatus expelled through the anus): 5 people, 12.20%
Itching: 5 people, 12.20%
Anaemia (lack of blood): 5 people, 12.20%
High Blood Pressure: 5 people, 12.20%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 5 people, 12.20%
Fever: 5 people, 12.20%

* Approximation only. Some reports may have incomplete information.

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