Hydroxyzine and Liver drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Liver (liver extract). Common drug interactions include dry eye among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Liver. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Liver?

Liver has active ingredients of liver extract. eHealthMe is studying from 1,316 Liver users. Check the latest studies of Liver.



On Aug, 05, 2026

31 people who take Hydroxyzine and Liver together, and have interactions are studied.

Hydroxyzine and Liver drug interactions.

What are the common drug interactions of Hydroxyzine and Liver, by gender? *:

female:

  1. Dry eye (lack of adequate tears)
  2. Rash
  3. Conjunctivitis (pink eye)
  4. Lacrimation increased
  5. Skin irritation
  6. Dizziness
  7. Brain neoplasm (tumour of brain)
  8. Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
  9. Depression
  10. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)

male:

  1. Alanine aminotransferase increased
  2. Aspartate aminotransferase increased
  3. Pneumonia
  4. Respiratory failure (inadequate gas exchange by the respiratory system)
  5. Aggression
  6. Alcohol use
  7. Diarrhoea
  8. Drug eruption (adverse drug reaction of the skin)
  9. Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
  10. Asthenia (weakness)

What are the common drug interactions of Hydroxyzine and Liver, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Rash
  2. Conjunctivitis (pink eye)
  3. Dry eye (lack of adequate tears)
  4. Lacrimation increased
  5. Skin irritation
  6. Depression
  7. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
  8. Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
  9. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
  10. Hospitalisation

50-59:

  1. Limb discomfort (discomfort in leg)
  2. Metastases to liver (cancer spreads to liver)
  3. Partial seizures (seizures which affect only a part of the brain at onset)
  4. Sensory loss (senses loss)
  5. Sleep disorder
  6. Asthenia (weakness)
  7. Bipolar disorder (mood disorder)
  8. Chronic kidney disease
  9. Constipation
  10. Fatigue (feeling of tiredness)

60+:

  1. Alanine aminotransferase increased
  2. Aspartate aminotransferase increased
  3. Blood alkaline phosphatase increased
  4. Blood bilirubin increased
  5. Pneumonia
  6. Drug eruption (adverse drug reaction of the skin)
  7. Gastrointestinal pain

What are the existing conditions these people have? *

  1. Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 7 people, 22.58%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 16.13%
  3. Joint Pain: 4 people, 12.90%
  4. Pain: 3 people, 9.68%
  5. Dermatitis Allergic (inflammation of the skin due allergic reaction): 3 people, 9.68%
  6. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 3 people, 9.68%
  7. Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 6.45%
  8. Herpes Simplex (herpes simplex is a common viral infection): 2 people, 6.45%
  9. Bone Disorder: 2 people, 6.45%
  10. Breast Cancer Female: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Hydroxyzine and Liver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydroxyzine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Liver:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Hydroxyzine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Liver and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on hydroxyzine hydrochloride and liver extract (the active ingredients of Hydroxyzine and Liver, respectively), and Hydroxyzine and Liver (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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