Hydroxyzine and Nikki drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Nikki (drospirenone; ethinyl estradiol). Common drug interactions include dermatitis atopic among females.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Nikki. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Nikki?

Nikki has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 197 Nikki users. Check the latest studies of Nikki.

On Jul, 20, 2026

11 people who take Hydroxyzine and Nikki together, and have interactions are studied.

Hydroxyzine and Nikki drug interactions.

What are the common drug interactions of Hydroxyzine and Nikki, by gender? *:

female:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Irritable bowel syndrome
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Enuresis (repeated inability to control urination)
Feeding disorder (when children refuse to eat certain food groups)
Hallucination (an experience involving the perception of something not present)
Maternal exposure during pregnancy (use of substance during pregnancy)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Muscular weakness (muscle weakness)
Post-traumatic stress disorder

male:

n/a

What are the common drug interactions of Hydroxyzine and Nikki, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Maternal exposure during pregnancy (use of substance during pregnancy)

30-39:

Adnexa uteri pain
Hysterectomy
Irritable bowel syndrome
Migraine (headache)
Depression
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Feeding disorder (when children refuse to eat certain food groups)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 6 people, 54.55%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 36.36%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 36.36%
Urticaria Chronic (long lasting rash of round, red welts on the skin that itch intensely): 1 person, 9.09%
Drowsiness: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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