Hydroxyzine and Prinzide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Prinzide (hydrochlorothiazide; lisinopril). Common drug interactions include weight increased among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Prinzide. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

On Jul, 05, 2026

15 people who take Hydroxyzine and Prinzide together, and have interactions are studied.

Hydroxyzine and Prinzide drug interactions.

What are the common drug interactions of Hydroxyzine and Prinzide, by gender? *:

female:

Weight increased
Arthralgia (joint pain)
Bankruptcy
Blood creatinine increased
Compulsive hoarding (unwillingness to discard large quantities of objects that cover the living areas)
Compulsive sexual behaviour (unable to manage his/her sexual behaviour)
Compulsive shopping
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fatigue (feeling of tiredness)

male:

Pneumonia
Anaemia (lack of blood)
Blood urea decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Compression fracture (fracture due to pressure caused by injury)
Dysuria (painful or difficult urination)
Ejection fraction decreased (systolic heart failure)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)

What are the common drug interactions of Hydroxyzine and Prinzide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Completed suicide (act of taking one's own life)
Overdose

50-59:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood creatinine increased
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Pneumonia
Anaemia (lack of blood)
Blood urea decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Compression fracture (fracture due to pressure caused by injury)
Dysuria (painful or difficult urination)
Ejection fraction decreased (systolic heart failure)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)

What are the existing conditions these people have? *

Diabetes: 2 people, 13.33%
Pain: 2 people, 13.33%
Hepatitis C: 2 people, 13.33%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 13.33%
Insomnia (sleeplessness): 2 people, 13.33%
Urinary Retention (the inability to completely or partially empty the bladder): 1 person, 6.67%
Itching: 1 person, 6.67%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 6.67%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 6.67%
Colitis (inflammation of colon): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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