Hydroxyzine and Tikosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Tikosyn (dofetilide). Common drug interactions include cardiac amyloidosis among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Tikosyn. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Tikosyn?

Tikosyn has active ingredients of dofetilide. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 12,202 Tikosyn users. Check the latest studies of Tikosyn.

On Jul, 22, 2026

18 people who take Hydroxyzine and Tikosyn together, and have interactions are studied.

Hydroxyzine and Tikosyn drug interactions.

What are the common drug interactions of Hydroxyzine and Tikosyn, by gender? *:

female:

Cardiac amyloidosis (protein deposition in heart)
Drug ineffective
Weight decreased
Cardiac failure congestive
Liver disorder (liver diseases)
Depression
Suicidal ideation
Abdominal pain
Blood pressure increased
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)

male:

Asthenia (weakness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Influenza
Limb injury
Pain in extremity
Sinusitis (inflammation of sinus)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Blood potassium decreased
Depression
Haemoglobin decreased

What are the common drug interactions of Hydroxyzine and Tikosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cyst (a closed sac)
Dizziness
Ear infection
Influenza
Sinusitis (inflammation of sinus)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

50-59:

Depression
Suicide attempt

60+:

Headache (pain in head)
Weight decreased
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Depression
Limb injury
Pain in extremity
Suicidal ideation
Blood potassium decreased
Blood pressure increased

What are the existing conditions these people have? *

Itching: 4 people, 22.22%
Sleep Disorder: 3 people, 16.67%
Hypersensitivity: 3 people, 16.67%
Cardiac Disorder: 3 people, 16.67%
Urinary Tract Infection: 2 people, 11.11%
Chest Pain: 2 people, 11.11%
Heart Rate Irregular: 2 people, 11.11%
High Blood Cholesterol: 2 people, 11.11%
Ill-Defined Disorder: 2 people, 11.11%
Joint Pain: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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