Hydroxyzine and Zaditor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hydroxyzine (hydroxyzine hydrochloride) and Zaditor (ketotifen fumarate). Common drug interactions include therapeutic response unexpected among females and discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Hydroxyzine and Zaditor. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

What is Zaditor?

Zaditor has active ingredients of ketotifen fumarate. It is often used in eye allergy. eHealthMe is studying from 4,448 Zaditor users. Check the latest studies of Zaditor.

On Aug, 12, 2026

29 people who take Hydroxyzine and Zaditor together, and have interactions are studied.

Hydroxyzine and Zaditor drug interactions.

What are the common drug interactions of Hydroxyzine and Zaditor, by gender? *:

female:

Therapeutic response unexpected
Anaphylactic reaction (serious allergic reaction)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Nasopharyngitis (inflammation of the nasopharynx)
Rhinorrhoea (watery mucus discharge from the nose)
Arthralgia (joint pain)
Eye irritation
Eye pain
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Irritable bowel syndrome

male:

Discomfort
Pain
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Platelet count decreased
Protein total increased
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Burning sensation
Death
Eosinophilic oesophagitis (allergic inflammatory condition of the oesophagus)

What are the common drug interactions of Hydroxyzine and Zaditor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthralgia (joint pain)
Chills (felling of cold)
Dysphagia (a condition in which swallowing is difficult or painful)
Emotional disorder
Flushing (the warm, red condition of human skin)
Joint stiffness
Mastocytosis (an excessive number of apparently normal mast cells in the skin and, occasionally, in other organs)
Mood swings (an extreme or rapid change in mood)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)

30-39:

Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Irritable bowel syndrome
Nasopharyngitis (inflammation of the nasopharynx)
Rhinorrhoea (watery mucus discharge from the nose)
Therapeutic response unexpected
Balance disorder
Lip swelling
Rash
Skin discolouration (change of skin colour)

40-49:

Anaphylactic reaction (serious allergic reaction)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthma
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Muscular weakness (muscle weakness)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary mass
Sinusitis (inflammation of sinus)

50-59:

Asthenia (weakness)
Blood potassium decreased
Blood triglycerides decreased
Discomfort
Drug ineffective
Epistaxis (bleed from the nose)
Hyperhidrosis (abnormally increased sweating)
Injection site erythema (redness at injection site)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)

60+:

Acute respiratory failure
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Eye irritation
Eye pain
Eyelid pain
Hypotension (abnormally low blood pressure)
Infusion site pruritus (severe itching at infusion site)
Lacrimation increased
Malaise (a feeling of general discomfort or uneasiness)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

What are the existing conditions these people have? *

Asthma: 7 people, 24.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 17.24%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 17.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 10.34%
Seasonal Allergy (allergic condition due to certain season): 2 people, 6.90%
Pneumonia: 2 people, 6.90%
Itching: 2 people, 6.90%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 6.90%
High Blood Pressure: 2 people, 6.90%
Dry Eyes (lack of adequate tears): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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