Hysingla and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hysingla (hydrocodone bitartrate) and Zide (hydrochlorothiazide). Common drug interactions include migraine among females and developmental delay among males.

The phase IV clinical study analyzes what interactions people have when they take Hysingla and Zide. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Hysingla?

Hysingla has active ingredients of hydrocodone bitartrate. eHealthMe is studying from 32,609 Hysingla users. Check the latest studies of Hysingla.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 12, 2026

17 people who take Hysingla and Zide together, and have interactions are studied.

What are the common drug interactions of Hysingla and Zide, by gender? *:

female:

Migraine (headache)
Asthenia (weakness)
Nausea (feeling of having an urge to vomit)
Pancreatitis acute (sudden inflammation of pancreas)
Sinusitis (inflammation of sinus)
Headache (pain in head)
Respiratory tract infection
Ear infection
Ear pain
Erythema (redness of the skin)

male:

Developmental delay
Drug dependence
Detoxification
Disability
Emotional distress
Euphoric mood (excessively happy but may become angry or irritable)
Feeling of despair
Gastritis (inflammation of stomach)
General physical health deterioration (weak health status)
Hypercholesterolaemia (high levels of cholesterol in the blood)

What are the common drug interactions of Hysingla and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Psoriasis (immune-mediated disease that affects the skin)

40-49:

n/a

50-59:

Headache (pain in head)
Agitation (state of anxiety or nervous excitement)
Asthenia (weakness)
Constipation
Costochondritis (chest wall pain)
Ear infection
Ear pain
Erythema (redness of the skin)
Facial pain
Fatigue (feeling of tiredness)

60+:

Acute respiratory failure
Anaphylactic reaction (serious allergic reaction)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Upper respiratory tract infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Hip arthroplasty
Peripheral swelling
Staphylococcal infection (an infection with staphylococcus bacteria)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 6 people, 35.29%
Pain: 3 people, 17.65%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 17.65%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 17.65%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 11.76%
Upper Respiratory Tract Infection: 1 person, 5.88%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 5.88%
Blood Glucose Increased: 1 person, 5.88%
Breakthrough Pain: 1 person, 5.88%
Diabetes: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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