Ibu and Caplyta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ibu (ibuprofen) and Caplyta (lumateperone tosylate). Common drug interactions include malaise among females and gait disturbance among males.

The phase IV clinical study analyzes what interactions people have when they take Ibu and Caplyta. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

What is Caplyta?

Caplyta has active ingredients of lumateperone tosylate. eHealthMe is studying from 3,109 Caplyta users. Check the latest studies of Caplyta.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

15 people who take Ibu and Caplyta together, and have interactions are studied.

What are the common drug interactions of Ibu and Caplyta, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Fall
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Vomiting
Anorgasmia (type of sexual dysfunction in which a person cannot achieve orgasm, even with adequate stimulation)
Contusion (a type of hematoma of tissue in which capillaries)
Loss of consciousness
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

male:

Gait disturbance
Performance status decreased
Insomnia (sleeplessness)
Poor quality sleep
Sleep disorder
Slow speech
Thirst
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Bradycardia (abnormally slow heart action)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)

What are the common drug interactions of Ibu and Caplyta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Balance disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Gait disturbance
Performance status decreased
Slow speech
Anorgasmia (type of sexual dysfunction in which a person cannot achieve orgasm, even with adequate stimulation)
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Loss of consciousness
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Ankle fracture
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Erythema (redness of the skin)
Eye pain
Eyelid margin crusting (crusting at the lid margins, generally worse on waking)
Fall
Foot fracture
Head injury
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)

40-49:

Nausea (feeling of having an urge to vomit)
Angioedema (rapid swelling of the dermis)
Depression
Incontinence (lack of moderation or self-control)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Mood altered (changes in mood)
Spondylitis (an inflammation of the vertebra with spinal cord involvement)
Vomiting

50-59:

Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)

60+:

Abdominal discomfort
Bradycardia (abnormally slow heart action)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Nasopharyngitis (inflammation of the nasopharynx)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tremor (trembling or shaking movements in one or more parts of your body)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Chest discomfort
Chills (felling of cold)

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 3 people, 20.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 13.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 13.33%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 2 people, 13.33%
Drowsiness: 2 people, 13.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 13.33%
Stress And Anxiety: 1 person, 6.67%
Postoperative Wound Infection: 1 person, 6.67%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 6.67%
Oppositional Defiant Disorder (a childhood disorder described by the diagnostic and statistical manual of mental disorders): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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