Imitrex and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imitrex (sumatriptan succinate) and Actos (pioglitazone hydrochloride). Common drug interactions include hypotension among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Imitrex and Actos. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Imitrex?

Imitrex has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 17,149 Imitrex users. Check the latest studies of Imitrex.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

57 people who take Imitrex and Actos together, and have interactions are studied.

What are the common drug interactions of Imitrex and Actos, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Abdominal pain
Chest pain
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Weight decreased
Insomnia (sleeplessness)
Blood pressure increased
Chest discomfort

male:

Dyspnoea (difficult or laboured respiration)
Chest pain
Hypoaesthesia (reduced sense of touch or sensation)
Lymphadenopathy (disease or enlargement of lymph nodes)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Pain in extremity
Pulmonary oedema (fluid accumulation in the lungs)
Abdominal distension
Abdominal pain
Abdominal pain lower

What are the common drug interactions of Imitrex and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Vomiting
Hyperglycaemia (high blood sugar)

20-29:

Asthma
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diarrhoea
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Impaired gastric emptying
Rift valley fever (a viral disease spread primarily by mosquitoes)
Stress
Weight increased
Burning sensation
Generalised oedema (swelling all over the body)

30-39:

Abdominal pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Acidosis (build-up of carbon dioxide in the blood)
Cardiac arrest
Cholecystitis (infection of gallbladder)
Death
Fluid overload (too much fluid in the blood)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)

40-49:

Cardiac murmur (an heart sound in valve abnormality)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cellulitis (infection under the skin)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic ulcer
Dizziness
Dyspnoea (difficult or laboured respiration)
Fall
Fatigue (feeling of tiredness)

50-59:

Blood glucose increased
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)
Chest pain
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Arthralgia (joint pain)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Cardiac failure congestive
Cellulitis (infection under the skin)

60+:

Weight decreased
Blood glucose increased
Blood glucose decreased
Blood potassium decreased
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Drug effect decreased
Fall
Fibromyalgia (a long-term condition which causes pain all over the body)
Flushing (the warm, red condition of human skin)

What are the existing conditions these people have? *

Depression: 9 people, 15.79%
Pain: 8 people, 14.04%
High Blood Cholesterol: 6 people, 10.53%
Headache (pain in head): 5 people, 8.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.77%
Cardiac Disorder: 5 people, 8.77%
Stress And Anxiety: 4 people, 7.02%
Sleep Disorder: 4 people, 7.02%
Type 2 Diabetes: 3 people, 5.26%
Multiple Allergies (allergy to multiple agents): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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