Imitrex and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imitrex (sumatriptan succinate) and Compazine (prochlorperazine maleate). Common drug interactions include blood potassium decreased among females and chills among males.

The phase IV clinical study analyzes what interactions people have when they take Imitrex and Compazine. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Imitrex?

Imitrex has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 17,149 Imitrex users. Check the latest studies of Imitrex.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in indigestion. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

On Jul, 08, 2026

47 people who take Imitrex and Compazine together, and have interactions are studied.

Imitrex and Compazine drug interactions.

What are the common drug interactions of Imitrex and Compazine, by gender? *:

female:

Blood potassium decreased
Cerebral disorder (brain disease)
Cerebral venous thrombosis (clot in brains venous blood system)
Cholecystitis acute (rapid infection of gallbladder)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Cough
Death
Dental caries
Drug dependence
Drug effect delayed

male:

Chills (felling of cold)
Headache (pain in head)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Arrhythmia (irregular heartbeat)
Blood glucose decreased
Blood magnesium decreased
Blood sodium decreased
Colitis ulcerative (inflammation of colon with ulcer)
Decreased interest

What are the common drug interactions of Imitrex and Compazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Asthenia (weakness)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Superior sagittal sinus thrombosis (blood clot in the dural venous sinuses, which drain blood from the brain)
Vision blurred

20-29:

Pulmonary embolism (blockage of the main artery of the lung)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholecystitis acute (rapid infection of gallbladder)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug hypersensitivity

30-39:

Chronic kidney disease
Glomerulonephritis membranoproliferative (a type of glomerulonephritis caused by deposits in the kidney glomerular mesangium and basement membrane (gbm) thickening)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Anaemia (lack of blood)
Asthma
Ataxia (loss of full control of bodily movements)
Back pain
Cerebral venous thrombosis (clot in brains venous blood system)

40-49:

Nephrolithiasis (calculi in the kidneys)
Pain
Pain in extremity
Plasma cell myeloma (cancer that begins in plasma cells)
Post lumbar puncture syndrome
Psoriasis (immune-mediated disease that affects the skin)
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary mass
Road traffic accident
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands)

50-59:

Blood pressure increased
Drug ineffective
Gastric disorder (disease of stomach)
Overdose
Therapeutic response decreased (less preventive response)
Back pain
Calcium deficiency (lack of calcium)
Haematemesis (vomiting of blood)
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc displacement

60+:

Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Haemorrhage (bleeding)
Hypercapnia (too much smoke)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Leukocytosis (increased white blood cells)
Malignant melanoma (skin cancer rises from melancytes)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 12 people, 25.53%
Diarrhea: 6 people, 12.77%
Stress And Anxiety: 5 people, 10.64%
Pain: 5 people, 10.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.64%
Ovarian Cancer (cancer of ovary): 4 people, 8.51%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 8.51%
High Blood Cholesterol: 4 people, 8.51%
Headache (pain in head): 4 people, 8.51%
Sleep Disorder: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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