Imitrex and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imitrex (sumatriptan succinate) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include hypertension among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Imitrex and Macrobid. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Imitrex?

Imitrex has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 17,149 Imitrex users. Check the latest studies of Imitrex.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 08, 2026

57 people who take Imitrex and Macrobid together, and have interactions are studied.

What are the common drug interactions of Imitrex and Macrobid, by gender? *:

female:

Hypertension (high blood pressure)
Insomnia (sleeplessness)
Iron deficiency anaemia
Road traffic accident
Pulmonary embolism (blockage of the main artery of the lung)
Cardiac failure congestive
Abdominal pain upper
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cardiac murmur (an heart sound in valve abnormality)

male:

Pneumonia
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cardiomyopathy (weakening of the heart muscle)
Cataract (clouding of the lens inside the eye)
Dyspnoea (difficult or laboured respiration)
Exostosis (formation of new bone on the surface of a bone)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Heart rate irregular
Hypertension (high blood pressure)
Impaired healing

What are the common drug interactions of Imitrex and Macrobid, by age (0-1 to 60+)? *:

0-1:

Convulsion neonatal (muscle contraction and relaxation rapidly in neonate)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Hydrocephalus (water on the brain)
Premature baby

2-9:

n/a

10-19:

Pulmonary embolism (blockage of the main artery of the lung)

20-29:

n/a

30-39:

Abdominal pain lower
Anaemia (lack of blood)
Anxiety
Bladder hypertrophy (bladder overgrowth- increase in cell size)
Cardiomyopathy (weakening of the heart muscle)
Chronic kidney disease
Delirium (wild excitement)
Depression
Detrusor sphincter dyssynergia (lack of external sphincter relaxation during voluntary voiding)
Device related infection

40-49:

Pulmonary hypertension primary (increase in blood pressure in the lung artery with no cause)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cough
Diarrhoea
Cardiomegaly (increased size of heart than normal)
Dry mouth
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Oesophageal spasm (contraction of oesophagus)

50-59:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cardiac failure congestive
Cardiac murmur (an heart sound in valve abnormality)
Coma (state of unconsciousness lasting more than six hours)
Constipation
Dental caries
Depression
Haemorrhage (bleeding)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypoaesthesia (reduced sense of touch or sensation)

60+:

Contusion (a type of hematoma of tissue in which capillaries)
Pneumonia
Back pain
Balance disorder
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiac murmur (an heart sound in valve abnormality)
Cardiomyopathy (weakening of the heart muscle)
Cataract (clouding of the lens inside the eye)

What are the existing conditions these people have? *

Depression: 14 people, 24.56%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 12 people, 21.05%
Metastases To Bone (cancer spreads to bone): 8 people, 14.04%
Pain: 7 people, 12.28%
Stress And Anxiety: 5 people, 8.77%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 5 people, 8.77%
Osteoporosis (bones weak and more likely to break): 5 people, 8.77%
Headache (pain in head): 4 people, 7.02%
Birth Control: 4 people, 7.02%
Muscle Spasms (muscle contraction): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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