Imitrex and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imitrex (sumatriptan succinate) and Savella (milnacipran hydrochloride). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Imitrex and Savella. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Imitrex?

Imitrex has active ingredients of sumatriptan succinate. It is often used in migraine. eHealthMe is studying from 17,149 Imitrex users. Check the latest studies of Imitrex.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

On Jul, 11, 2026

42 people who take Imitrex and Savella together, and have interactions are studied.

What are the common drug interactions of Imitrex and Savella, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Drug ineffective
Drug administration error
Erosive oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time)
Vomiting
Arthralgia (joint pain)
Cardiogenic shock (inadequate circulation of blood)
Chest pain
Colitis (inflammation of colon)
Insomnia (sleeplessness)

male:

n/a

What are the common drug interactions of Imitrex and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac failure congestive
Cardiogenic shock (inadequate circulation of blood)
Multi-organ failure (multisystem organ failure)
Aphasia (damage to the parts of the brain that control language)
Mitral valve incompetence (inefficient heart valve)
Abdominal pain
Bacterial test positive
Butterfly rash
Cardiomegaly (increased size of heart than normal)
Chest pain

30-39:

Suicidal ideation
Hyperhidrosis (abnormally increased sweating)

40-49:

Drug ineffective
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Adverse event
Anaphylactic reaction (serious allergic reaction)
Appendix disorder
Bladder dilatation
Bladder disorder
Breast discharge
Breast disorder

50-59:

Fall
Foot fracture
Hypersensitivity
Intestinal obstruction
Lung disorder (lung disease)
Malaise (a feeling of general discomfort or uneasiness)
Renal artery stenosis (narrowing of renal artery)
Throat tightness
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting

60+:

Alcohol intolerance
Anxiety
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Ankle fracture
Anosognosia (ignorance of the presence of disease)
Aortic arteriosclerosis (hardening of the aortic arteries)
Apathy
Arthropathy

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 6 people, 14.29%
Pain: 3 people, 7.14%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 7.14%
High Blood Pressure: 3 people, 7.14%
Headache (pain in head): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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