Imodium a-d and Adcirca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium a-d (loperamide hydrochloride) and Adcirca (tadalafil). Common drug interactions include flushing among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium a-d and Adcirca. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.

What is Adcirca?

Adcirca has active ingredients of tadalafil. It is often used in pulmonary hypertension. eHealthMe is studying from 54,957 Adcirca users. Check the latest studies of Adcirca.

On Jul, 09, 2026

39 people who take Imodium a-d and Adcirca together, and have interactions are studied.

Imodium a-d and Adcirca drug interactions.

What are the common drug interactions of Imodium A-D and Adcirca, by gender? *:

female:

Flushing (the warm, red condition of human skin)
Swelling
Catheter site discharge
Catheter site erythema (redness of skin at catheter site)
Catheter site infection (infection at the site of insertion)
Culture wound positive
Device dislocation
Device related infection
Headache (pain in head)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)

male:

Death
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Oedema peripheral (superficial swelling)
Oxygen saturation decreased
Temperature intolerance (inability to go in temperature)

What are the common drug interactions of Imodium A-D and Adcirca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Infusion site haemorrhage (bleeding from infusion site)
Infusion site pain
Infusion site reaction
Infusion site swelling
Insomnia (sleeplessness)
Oedema peripheral (superficial swelling)
Platelet count decreased
Productive cough
Dyspnoea (difficult or laboured respiration)
Catheter site discharge

40-49:

Abdominal pain
Anticoagulation drug level below therapeutic
Cellulitis (infection under the skin)
Chills (felling of cold)
Decreased appetite
Drug abuse
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Injection site erythema (redness at injection site)
Injection site pain
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)

50-59:

Swelling
Abdominal pain upper
Nausea (feeling of having an urge to vomit)
Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Blood calcium increased
Chest pain
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Flushing (the warm, red condition of human skin)

60+:

Headache (pain in head)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Vomiting
Cystitis (inflammation of the wall of the bladder)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Anaemia (lack of blood)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Asthenia (weakness)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 32 people, 82.05%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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