Imodium a-d and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium a-d (loperamide hydrochloride) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include seasonal affective disorder among females and drug exposure during pregnancy among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium a-d and Macrobid. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium a-d?

Imodium a-d has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 8,944 Imodium a-d users. Check the latest studies of Imodium a-d.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 06, 2026

14 people who take Imodium a-d and Macrobid together, and have interactions are studied.

Imodium a-d and Macrobid drug interactions.

What are the common drug interactions of Imodium A-D and Macrobid, by gender? *:

female:

Seasonal affective disorder (a type of depression that occurs at a certain time of the year, usually in the winter)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Urinary retention (the inability to completely or partially empty the bladder)
Drug administration error
Abdominal pain upper
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dilatation ventricular
Dizziness
Failure to thrive (inadequate weight gain and physical growth in children)
Feeling hot

male:

Drug exposure during pregnancy
Hypospadias (an abnormal condition in males in which the urethra opens on the under surface of the penis)

What are the common drug interactions of Imodium A-D and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dysplasia (enlargement of an organ or tissue)
Fall
Loss of consciousness
Mobility decreased (ability to move is reduced)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Seasonal affective disorder (a type of depression that occurs at a certain time of the year, usually in the winter)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Urinary retention (the inability to completely or partially empty the bladder)

40-49:

n/a

50-59:

Type 2 diabetes mellitus

60+:

Abdominal pain upper
Constipation
Prothrombin time shortened
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pulmonary veno-occlusive disease (obstructive disease of the pulmonary veins)
Rectal prolapse (falling of rectum from normal place)
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)
Tricuspid valve incompetence (inefficient heart valve)
Weight decreased

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 28.57%
Multiple Myeloma (cancer of the plasma cells): 4 people, 28.57%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 2 people, 14.29%
Pain: 2 people, 14.29%
Depression: 2 people, 14.29%
Urethritis (inflammation of the urethra): 1 person, 7.14%
Sleep Disorder: 1 person, 7.14%
Neck Pain: 1 person, 7.14%
Nausea And Vomiting: 1 person, 7.14%
Nausea (feeling of having an urge to vomit): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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