Imodium multi-symptom relief and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium multi-symptom relief (loperamide hydrochloride; simethicone) and Reglan (metoclopramide hydrochloride). Common drug interactions include syncope among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium multi-symptom relief and Reglan. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium multi-symptom relief?

Imodium multi-symptom relief has active ingredients of loperamide hydrochloride; simethicone. It is often used in diarrhea. eHealthMe is studying from 5,486 Imodium multi-symptom relief users. Check the latest studies of Imodium multi-symptom relief.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

14 people who take Imodium multi-symptom relief and Reglan together, and have interactions are studied.

Imodium multi-symptom relief and Reglan drug interactions.

What are the common drug interactions of Imodium Multi-Symptom Relief and Reglan, by gender? *:

female:

Syncope (loss of consciousness with an inability to maintain postural tone)
Atelectasis (partial or complete collapse of the lung)
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pulmonary embolism (blockage of the main artery of the lung)
Death
Pneumonia

male:

Anxiety
Arthralgia (joint pain)
Decreased interest
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Duodenitis (inflammation of the duodenum)
Dysphagia (a condition in which swallowing is difficult or painful)
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Extrasystoles
Fatigue (feeling of tiredness)

What are the common drug interactions of Imodium Multi-Symptom Relief and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Atelectasis (partial or complete collapse of the lung)
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Localised infection (infection at the single location)
Cardiac failure congestive
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Cataract (clouding of the lens inside the eye)
Abdominal discomfort
Abdominal distension
Anaemia (lack of blood)
Anxiety

50-59:

Death

60+:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Large intestine perforation (hole in large intestine)
Oral pain
Pneumonia
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Renal failure chronic (long lasting kidney dysfunction)
Restless legs syndrome (a powerful urge to move your legs)
Small intestinal obstruction (blockage in small intestine)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tardive dyskinesia (a disorder that involves involuntary movements)

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 21.43%
Nausea And Vomiting: 3 people, 21.43%
Nausea (feeling of having an urge to vomit): 3 people, 21.43%
Depression: 3 people, 21.43%
Premenstrual Syndrome: 2 people, 14.29%
Ovarian Cysts (fluid filled sacs of the ovary): 2 people, 14.29%
Abdominal Pain: 2 people, 14.29%
Muscle Aches (muscle pain): 1 person, 7.14%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.14%
Malignant Ascites (a condition in which a person with cancer has an accumulation of fluid in the abdomen): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium multi-symptom relief and Reglan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously