Imodium and Apriso drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Apriso (mesalamine). Common drug interactions include body mass index increased among females and anastomotic complication among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Apriso. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Apriso?

Apriso has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 3,439 Apriso users. Check the latest studies of Apriso.

On Jul, 05, 2026

63 people who take Imodium and Apriso together, and have interactions are studied.

What are the common drug interactions of Imodium and Apriso, by gender? *:

female:

Body mass index increased
Cataract (clouding of the lens inside the eye)
Cough
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug hypersensitivity
Dyslipidaemia (abnormal amount of lipids)
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Facial neuralgia (pain of face)

male:

Anastomotic complication (complication of surgical connection between two structures)
Injection site pain
Anxiety
Chills (felling of cold)
Colonic stenosis (abnormal narrowing of colon)
Drug hypersensitivity
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Eructation (release of gas from the digestive tract)
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Imodium and Apriso, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Injection site haemorrhage (bleeding from injection site)
Injection site pain

20-29:

Abdominal pain
Injection site pain
Blood magnesium decreased
Blood potassium decreased
Small intestinal obstruction (blockage in small intestine)
Small intestinal stenosis (abnormal narrowing of small intestine)
Vitamin c decreased

30-39:

Injection site haemorrhage (bleeding from injection site)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Rash
Dehydration (dryness resulting from the removal of water)
Drug ineffective

40-49:

Amylase increased
Arthralgia (joint pain)
Cholecystitis (infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Gait disturbance
Gastrointestinal viral infection (virus infection of gastrointestinal tract)
Hypertension (high blood pressure)
Lipase increased
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Poor venous access

50-59:

Injection site pain
Enteritis (inflammation of the small intestine)
Gastritis (inflammation of stomach)
Injection site bruising
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Rash

60+:

Anastomotic complication (complication of surgical connection between two structures)
Intestinal stenosis (partial obstruction that causes the centre opening of the intestine to become narrower)
Injection site pain
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Metastases to liver (cancer spreads to liver)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Peripheral swelling
Rectal haemorrhage (bleeding from anus)
Nausea (feeling of having an urge to vomit)
Accident

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 25 people, 39.68%
High Blood Cholesterol: 10 people, 15.87%
Pain: 9 people, 14.29%
High Blood Pressure: 8 people, 12.70%
Muscle Spasms (muscle contraction): 6 people, 9.52%
Stress And Anxiety: 5 people, 7.94%
Oedema (fluid collection in tissue): 5 people, 7.94%
Nausea (feeling of having an urge to vomit): 5 people, 7.94%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.94%
Depression: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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