Imodium and Aygestin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Aygestin (norethindrone acetate). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Aygestin. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Aygestin?

Aygestin has active ingredients of norethindrone acetate. It is often used in endometriosis. eHealthMe is studying from 1,107 Aygestin users. Check the latest studies of Aygestin.

On Aug, 11, 2026

18 people who take Imodium and Aygestin together, and have interactions are studied.

What are the common drug interactions of Imodium and Aygestin, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Anxiety
Migraine (headache)
Nasal dryness (dry nose)
Palpitations (feelings or sensations that your heart is pounding or racing)
Rash
Strabismus (a disorder in which the two eyes do not line up in the same direction)
Visual impairment
Abdominal abscess (collection of pus in abdomen)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)

male:

n/a

What are the common drug interactions of Imodium and Aygestin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Heart rate decreased
Hypotension (abnormally low blood pressure)
Palpitations (feelings or sensations that your heart is pounding or racing)
Precancerous skin lesion
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Surgery

40-49:

Abdominal abscess (collection of pus in abdomen)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Blood cholesterol increased
Blood thyroid stimulating hormone increased
Blood triglycerides increased
Bone density decreased
Breast cancer
Breast disorder
Breast mass
Breast pain
Bunion (a painful swelling on the first joint of the big toe)
Cataract (clouding of the lens inside the eye)

60+:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Renal tubular necrosis (death of kidney tubules)
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 77.78%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 77.78%
Headache (pain in head): 3 people, 16.67%
Pain: 3 people, 16.67%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 11.11%
Febrile Neutropenia (fever with reduced white blood cells): 2 people, 11.11%
High Blood Pressure: 2 people, 11.11%
Flatulence (flatus expelled through the anus): 2 people, 11.11%
Fever: 2 people, 11.11%
Constipation: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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