Imodium and Cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Cortef (hydrocortisone). Common drug interactions include urinary tract infection among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Cortef. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

On Aug, 12, 2026

71 people who take Imodium and Cortef together, and have interactions are studied.

What are the common drug interactions of Imodium and Cortef, by gender? *:

female:

Urinary tract infection
Decreased appetite
Bone disorder
Electrolyte imbalance
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Upper respiratory tract infection
Vomiting
Acquired porphyria (group of disorders that result in a build up of chemicals called porphyrins in the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

male:

Nausea (feeling of having an urge to vomit)
Vomiting
Asthenia (weakness)
Back pain
Bronchial disorder
Cough
Disease progression
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)
Gout (uric acid crystals building up in the body)

What are the common drug interactions of Imodium and Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)

10-19:

n/a

20-29:

n/a

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)
Renal failure (kidney dysfunction)

40-49:

Renal cell carcinoma (a kidney cancer)
Abdominal pain upper
Endometrial cancer stage iv
Epistaxis (bleed from the nose)
Injection site induration
Injection site pain
Pain
Body temperature decreased
Heart rate decreased
Blood pressure diastolic decreased

50-59:

Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Fungal infection
Hypertension (high blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)
Vomiting
Weight decreased
Ageusia (loss of taste functions of the tongue)
Asthenia (weakness)
Back pain

60+:

Pain
Nausea (feeling of having an urge to vomit)
Acquired porphyria (group of disorders that result in a build up of chemicals called porphyrins in the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Bacteraemia (presence of bacteria in the blood)
Bone disorder
Bone fragmentation
Breast cancer recurrent

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 13 people, 18.31%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 10 people, 14.08%
Pain: 9 people, 12.68%
Nausea And Vomiting: 8 people, 11.27%
Insomnia (sleeplessness): 8 people, 11.27%
Stress And Anxiety: 6 people, 8.45%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 5 people, 7.04%
Malignant Melanoma (skin cancer rises from melancytes): 5 people, 7.04%
Itching: 5 people, 7.04%
Depression: 5 people, 7.04%

* Approximation only. Some reports may have incomplete information.

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