Imodium and Nuvaring drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Nuvaring (ethinyl estradiol; etonogestrel). Common drug interactions include headache among females and cholelithiasis among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Nuvaring. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Nuvaring?

Nuvaring has active ingredients of ethinyl estradiol; etonogestrel. It is often used in birth control. eHealthMe is studying from 28,730 Nuvaring users. Check the latest studies of Nuvaring.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

33 people who take Imodium and Nuvaring together, and have interactions are studied.

What are the common drug interactions of Imodium and Nuvaring, by gender? *:

female:

Headache (pain in head)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Nausea (feeling of having an urge to vomit)
Viral infection
Vulval cellulitis (inflammation of skin around vagina)
Wheezing (a high-pitched whistling sound made while you breath)
Back pain
Chest discomfort
Infusion related reaction
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)

male:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

What are the common drug interactions of Imodium and Nuvaring, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Overdose
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Colitis (inflammation of colon)
Hypotension (abnormally low blood pressure)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Syncope (loss of consciousness with an inability to maintain postural tone)

30-39:

Blood iron decreased
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Fall
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)
Urinary tract infection
Viral infection
Vulval cellulitis (inflammation of skin around vagina)
Wheezing (a high-pitched whistling sound made while you breath)
Arthralgia (joint pain)

40-49:

Arterial thrombosis (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system)
Arteriosclerosis (thickening and hardening of arteries)
Hypercoagulation (increased tendency for clotting of the blood)
Hypoaesthesia (reduced sense of touch or sensation)
Ingrowing nail
Injection site haematoma (localized swelling filled with blood at injection site)
International normalised ratio increased
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 9 people, 27.27%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 7 people, 21.21%
Insomnia (sleeplessness): 7 people, 21.21%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 9.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 9.09%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 6.06%
Seasonal Allergy (allergic condition due to certain season): 2 people, 6.06%
Headache (pain in head): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium and Nuvaring?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously