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Imodium and Oxbryta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Oxbryta (voxelotor). Common drug interactions include abdominal distension among females and acute chest syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Oxbryta. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Oxbryta?

Oxbryta has active ingredients of voxelotor. eHealthMe is studying from 24,969 Oxbryta users. Check the latest studies of Oxbryta.

On Jul, 13, 2026

29 people who take Imodium and Oxbryta together, and have interactions are studied.

Imodium and Oxbryta drug interactions.

What are the common drug interactions of Imodium and Oxbryta, by gender? *:

female:

  1. Abdominal distension
  2. Fatigue (feeling of tiredness)
  3. Asthenia (weakness)
  4. Lethargy (tiredness)
  5. Skin disorder (skin disease)
  6. Vision blurred
  7. Vomiting
  8. Back pain
  9. Haemoglobin decreased
  10. Abdominal discomfort

male:

  1. Acute chest syndrome (acute chest pain, fever and difficulty breathing)
  2. Headache (pain in head)
  3. Pneumonia
  4. Staphylococcal bacteraemia (a bacterial infection of blood)
  5. Drug ineffective

What are the common drug interactions of Imodium and Oxbryta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Decreased appetite
  2. Eye swelling
  3. Heart rate increased
  4. Hypersensitivity
  5. Lip swelling
  6. Pruritus (severe itching of the skin)
  7. Pyrexia (fever)
  8. Rash
  9. Swelling face
  10. Viral infection

10-19:

n/a

20-29:

  1. Abdominal pain
  2. Back pain
  3. Migraine (headache)

30-39:

  1. Drug ineffective

40-49:

  1. Pneumonia
  2. Staphylococcal bacteraemia (a bacterial infection of blood)
  3. Acute chest syndrome (acute chest pain, fever and difficulty breathing)

50-59:

  1. Constipation
  2. Abdominal pain upper
  3. Headache (pain in head)
  4. Nausea (feeling of having an urge to vomit)
  5. Abdominal distension
  6. Adverse event
  7. Back pain
  8. Flatulence (flatus expelled through the anus)

60+:

  1. Constipation

* Approximation only. Some reports may have incomplete information.

Do you take Imodium and Oxbryta?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Imodium and Oxbryta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Imodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Oxbryta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Imodium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Oxbryta and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride and voxelotor (the active ingredients of Imodium and Oxbryta, respectively), and Imodium and Oxbryta (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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