Imodium and Psyllium husk drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Psyllium husk (blond psyllium). Common drug interactions include abdominal discomfort among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Psyllium husk. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Psyllium husk?

Psyllium husk has active ingredients of blond psyllium. It is often used in constipation. eHealthMe is studying from 1,493 Psyllium husk users. Check the latest studies of Psyllium husk.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 04, 2026

23 people who take Imodium and Psyllium husk together, and have interactions are studied.

Imodium and Psyllium husk drug interactions.

What are the common drug interactions of Imodium and Psyllium Husk, by gender? *:

female:

Abdominal discomfort
Drug hypersensitivity
Food allergy
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bacteriuria (presence of bacteria in urine)
Chronic kidney disease
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)

male:

Dyspnoea (difficult or laboured respiration)
Blood pressure decreased
Fall
Head injury
Hospitalisation
Pneumonia
Renal disorder (kidney disease)
Syncope (loss of consciousness with an inability to maintain postural tone)
Bradycardia (abnormally slow heart action)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Imodium and Psyllium Husk, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Bacteriuria (presence of bacteria in urine)
Chronic kidney disease
Hyperchromic anaemia (anaemia in which the red blood cells (erythrocytes) are paler than normal)
Hyperkalaemia (damage to or disease of the kidney)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Magnesium deficiency (lack of magnesium)

50-59:

n/a

60+:

Dyspnoea (difficult or laboured respiration)
Abdominal discomfort
Oxygen saturation decreased
Pulmonary arterial pressure increased
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Dehydration (dryness resulting from the removal of water)
Drug ineffective
Epistaxis (bleed from the nose)

What are the existing conditions these people have? *

Pain: 7 people, 30.43%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 17.39%
Urinary Tract Infection: 4 people, 17.39%
Rashes (redness): 3 people, 13.04%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 8.70%
Hypokalemia (low potassium): 2 people, 8.70%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.70%
Cough: 2 people, 8.70%
Drowsiness: 2 people, 8.70%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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