Imodium and Rivaroxaban drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Rivaroxaban (rivaroxaban). Common drug interactions include amyloidosis among females and cytokine release syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Rivaroxaban. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Rivaroxaban?

Rivaroxaban has active ingredients of rivaroxaban. It is often used in blood clots. eHealthMe is studying from 26,543 Rivaroxaban users. Check the latest studies of Rivaroxaban.

On Jul, 14, 2026

75 people who take Imodium and Rivaroxaban together, and have interactions are studied.

Imodium and Rivaroxaban drug interactions.

What are the common drug interactions of Imodium and Rivaroxaban, by gender? *:

female:

Amyloidosis (a tumour within which amyloid is produced)
Ascites (accumulation of fluid in the abdominal cavity)
Bacterial infection
Colitis (inflammation of colon)
Dehydration (dryness resulting from the removal of water)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Erythema (redness of the skin)
Hip fracture
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Influenza

male:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Confusional state
Weight increased
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Aphonia (inability to produce voice)
Back pain
Blood pressure increased
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Imodium and Rivaroxaban, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Skin disorder (skin disease)
Cholecystitis (infection of gallbladder)
Surgery
Weight decreased
Feeding disorder (when children refuse to eat certain food groups)
Weight increased
Ligament sprain (ligament stretched)
Abnormal faeces (abnormal stool)
Poor venous access

20-29:

n/a

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Klebsiella test positive
Vomiting
Constipation
Dyspepsia (indigestion)
Headache (pain in head)
Insomnia (sleeplessness)

50-59:

International normalised ratio increased

60+:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Confusional state
Left ventricular failure (left ventricle fails to contract forcefully)
Muscular weakness (muscle weakness)
Rectal haemorrhage (bleeding from anus)
Respiratory failure (inadequate gas exchange by the respiratory system)
Fall
Asthenia (weakness)
Balance disorder
Blood pressure decreased

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 16 people, 21.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 12 people, 16.00%
Stress And Anxiety: 11 people, 14.67%
Pain: 7 people, 9.33%
Abdominal Discomfort: 6 people, 8.00%
Joint Pain: 6 people, 8.00%
Fever: 6 people, 8.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 8.00%
Neuropathy Peripheral (surface nerve damage): 5 people, 6.67%
Stomatitis (inflammation of mucous membrane of mouth): 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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