Imodium and Zaleplon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Imodium (loperamide hydrochloride) and Zaleplon (zaleplon). Common drug interactions include diabetic ketoacidosis among females and thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Imodium and Zaleplon. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Zaleplon?

Zaleplon has active ingredients of zaleplon. It is often used in insomnia. eHealthMe is studying from 1,935 Zaleplon users. Check the latest studies of Zaleplon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

14 people who take Imodium and Zaleplon together, and have interactions are studied.

What are the common drug interactions of Imodium and Zaleplon, by gender? *:

female:

Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Disease progression
Drug administration error
Poor venous access
Type 2 diabetes mellitus

male:

Thrombosis (formation of a blood clot inside a blood vessel)
Asthenia (weakness)
Loss of consciousness
Memory impairment
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Constipation
Dry mouth
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hyporesponsive to stimuli (abnormally low degree of responsiveness on an agent, action, or condition)
Muscle spasms (muscle contraction)

What are the common drug interactions of Imodium and Zaleplon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug administration error
Poor venous access

40-49:

n/a

50-59:

n/a

60+:

Disease progression
Muscle spasms (muscle contraction)
Pleural effusion (water on the lungs)
Thrombosis (formation of a blood clot inside a blood vessel)

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 28.57%
Musculoskeletal Chest Pain (pain in chest muscle or nerve or bones): 3 people, 21.43%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 21.43%
Multiple Myeloma (cancer of the plasma cells): 3 people, 21.43%
Haemoglobin Decreased: 2 people, 14.29%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 14.29%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 14.29%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 2 people, 14.29%
Malignant Melanoma (skin cancer rises from melancytes): 2 people, 14.29%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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