Inderal and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Inderal (propranolol hydrochloride) and Savella (milnacipran hydrochloride). Common drug interactions include depressed mood among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Inderal and Savella. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Inderal?

Inderal has active ingredients of propranolol hydrochloride. It is often used in migraine. eHealthMe is studying from 16,771 Inderal users. Check the latest studies of Inderal.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

On Jul, 09, 2026

66 people who take Inderal and Savella together, and have interactions are studied.

What are the common drug interactions of Inderal and Savella, by gender? *:

female:

Depressed mood
Disturbance in attention
Faeces discoloured
Feeling drunk
Hospitalisation
Drug ineffective
Nausea (feeling of having an urge to vomit)
Dry eye (lack of adequate tears)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)

male:

Insomnia (sleeplessness)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Nightmare (unpleasant dream)
Petit mal epilepsy (absence seizure)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Pruritus (severe itching of the skin)
Rash papular (redness with papule)

What are the common drug interactions of Inderal and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cough
Fatigue (feeling of tiredness)
Upper-airway cough syndrome
Nightmare (unpleasant dream)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Therapeutic response unexpected

40-49:

Dry eye (lack of adequate tears)
Age-related macular degeneration
Back pain
Bipolar ii disorder (characterized by at least one episode of hypomania and at least one episode of major depression)
Drug ineffective
General physical health deterioration (weak health status)
Suicidal ideation
Borderline personality disorder
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Intervertebral disc protrusion (spinal disc protrusion)

50-59:

Swollen tongue (swelling of tongue)
Abnormal faeces (abnormal stool)
Alopecia (absence of hair from areas of the body)
Aphasia (damage to the parts of the brain that control language)
Dry mouth
Dyspnoea (difficult or laboured respiration)
Ear infection
Flushing (the warm, red condition of human skin)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Headache (pain in head)

60+:

Dehydration (dryness resulting from the removal of water)
Influenza
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Injection site pruritus (severe itching at injection site)
Injection site rash
Insomnia (sleeplessness)
Perineal infection
Pruritus (severe itching of the skin)
Rash papular (redness with papule)
Scratch

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 27 people, 40.91%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 21.21%
Muscle Spasms (muscle contraction): 8 people, 12.12%
Depression: 8 people, 12.12%
Stress And Anxiety: 6 people, 9.09%
Irritable Bowel Syndrome: 5 people, 7.58%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 7.58%
Neuralgia (pain in one or more nerves): 5 people, 7.58%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 7.58%
Back Pain: 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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