Integrilin and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Integrilin (eptifibatide) and Diphen (diphenhydramine hydrochloride). Common drug interactions include gastrointestinal haemorrhage among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Integrilin and Diphen. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Integrilin?

Integrilin has active ingredients of eptifibatide. eHealthMe is studying from 3,037 Integrilin users. Check the latest studies of Integrilin.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 14, 2026

15 people who take Integrilin and Diphen together, and have interactions are studied.

Integrilin and Diphen drug interactions.

What are the common drug interactions of Integrilin and Diphen, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Agitation (state of anxiety or nervous excitement)
Angioedema (rapid swelling of the dermis)
Aphasia (damage to the parts of the brain that control language)
Cardiogenic shock (inadequate circulation of blood)
Ejection fraction decreased (systolic heart failure)
Gangrene (body tissue dies)
Haematocrit decreased
Haematoma (collection of blood outside the blood vessels)
Haemoglobin decreased

male:

Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Puncture site reaction
Pyrexia (fever)
Renal injury (kidney injury)
Rigors (an episode of shaking or exaggerated shivering)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vomiting
Chronic kidney disease
Diarrhoea

What are the common drug interactions of Integrilin and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Disability
Fear
Injury
Multi-organ failure (multisystem organ failure)
Pain
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Puncture site reaction
Wound secretion

60+:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Hypertension (high blood pressure)
Ejection fraction decreased (systolic heart failure)
Gangrene (body tissue dies)
Haematemesis (vomiting of blood)
Haematocrit decreased
Haematoma (collection of blood outside the blood vessels)
Haemoglobin decreased
Haemorrhage (bleeding)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)

What are the existing conditions these people have? *

Sedation: 1 person, 6.67%
Pain: 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
Discomfort: 1 person, 6.67%
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 1 person, 6.67%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Integrilin and Diphen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously